TY - JOUR
T1 - Mapping the organization of axis of motion selective features in human area mt using high-field fmri
AU - Zimmermann, Jan
AU - Goebel, Rainer
AU - de Martino, Federico
AU - Van de Moortele, Pierre-Francois
AU - Feinberg, David
AU - Adriany, Gregor
AU - Chaimow, Denis
AU - Shmuel, Amir
AU - Ugurbil, Kamil
AU - Yacoub, Essa
PY - 2011/12/7
Y1 - 2011/12/7
N2 - Functional magnetic resonance imaging (fMRI) at high magnetic fields has made it possible to investigate the columnar organization of the human brain in vivo with high degrees of accuracy and sensitivity. Until now, these results have been limited to the organization principles of early visual cortex (V1). While the middle temporal area (MT) has been the first identified extra-striate visual area shown to exhibit a columnar organization in monkeys, evidence of MT's columnar response properties and topographic layout in humans has remained elusive. Research using various approaches suggests similar response properties as in monkeys but failed to provide direct evidence for direction or axis of motion selectivity in human area MT. By combining state of the art pulse sequence design, high spatial resolution in all three dimensions (0.8 mm isotropic), optimized coil design, ultrahigh field magnets (7 Tesla) and novel high resolution cortical grid sampling analysis tools, we provide the first direct evidence for large-scale axis of motion selective feature organization in human area MT closely matching predictions from topographic columnar-level simulations.
AB - Functional magnetic resonance imaging (fMRI) at high magnetic fields has made it possible to investigate the columnar organization of the human brain in vivo with high degrees of accuracy and sensitivity. Until now, these results have been limited to the organization principles of early visual cortex (V1). While the middle temporal area (MT) has been the first identified extra-striate visual area shown to exhibit a columnar organization in monkeys, evidence of MT's columnar response properties and topographic layout in humans has remained elusive. Research using various approaches suggests similar response properties as in monkeys but failed to provide direct evidence for direction or axis of motion selectivity in human area MT. By combining state of the art pulse sequence design, high spatial resolution in all three dimensions (0.8 mm isotropic), optimized coil design, ultrahigh field magnets (7 Tesla) and novel high resolution cortical grid sampling analysis tools, we provide the first direct evidence for large-scale axis of motion selective feature organization in human area MT closely matching predictions from topographic columnar-level simulations.
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U2 - 10.1371/journal.pone.0028716
DO - 10.1371/journal.pone.0028716
M3 - Article
C2 - 22163328
AN - SCOPUS:82855177848
SN - 1932-6203
VL - 6
JO - PloS one
JF - PloS one
IS - 12
M1 - e28716
ER -