Abstract
A class of one-compartment models for pressure controlled mechanical ventilation is studied. The resistive pressure term in the general model is of the form: R1Q + R2Q|Q| where Q denotes the flow in and out of the compartment. This Rohrer-type model (R1 ≠ 0 and R 2 ≠ 0) is compared against the special cases: (i) R1 = RL and R2 = 0 (linear model); (ii) R1 = 0 and R2 = RN (nonlinear model). For clinical ranges of resistances (R1 and R2), compliance (C), applied pressure (Pset), frequency (f), and inspiratory time-fraction (D), the Rohrer model is used to compute the key outcome variables: tidal volume, average volume, end-expiratory pressure, and mean alveolar pressure. These values are compared against those obtained using equivalent RL and R N values. It is demonstrated that for clinically relevant ranges of the physiologic and ventilator parameters, little difference is observed between the Rohrer and nonlinear model.
Original language | English (US) |
---|---|
Pages (from-to) | 495-502 |
Number of pages | 8 |
Journal | Mathematical and Computer Modelling |
Volume | 38 |
Issue number | 5-6 |
DOIs | |
State | Published - Oct 10 2003 |
Keywords
- Mathematical model
- Mechanical ventilation
- Rohrer model