Measurements of immune responses for establishing correlates of vaccine protection against HIV

Wendy A. Burgers; Amapola Manrique; David Masopust; Lyle R. McKinnon; Matthew R. Reynolds; Morgane Rolland; Catherine Blish; Gerald K. Chege; Rhonda Curran; William Fischer; Carolina Herrera; D. Noah Sather

doi:10.1089/aid.2011.0239

Measurements of immune responses for establishing correlates of vaccine protection against HIV

Wendy A. Burgers, Amapola Manrique, David Masopust, Lyle R. McKinnon, Matthew R. Reynolds, Morgane Rolland, Catherine Blish, Gerald K. Chege, Rhonda Curran, William Fischer, Carolina Herrera, D. Noah Sather

Microbiology

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Abstract

Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.

Original language	English (US)
Pages (from-to)	641-648
Number of pages	8
Journal	AIDS Research and Human Retroviruses
Volume	28
Issue number	7
DOIs	https://doi.org/10.1089/aid.2011.0239
State	Published - Jul 1 2012

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AU - Masopust, David

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AU - Blish, Catherine

AU - Chege, Gerald K.

AU - Curran, Rhonda

AU - Fischer, William

AU - Herrera, Carolina

AU - Sather, D. Noah

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Measurements of immune responses for establishing correlates of vaccine protection against HIV

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