Abstract
The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-27 |
| Number of pages | 7 |
| Journal | Nature immunology |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2010 |
Bibliographical note
Funding Information:Supported by the US National Institutes of Health (P01 AI35296 and R01 AI080764).
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
