Mechanisms of congenital cytomegalovirus-induced deafness

Mark R. Schleiss; Daniel I. Choo

doi:10.1016/j.ddmec.2006.02.009

Mechanisms of congenital cytomegalovirus-induced deafness

Mark R. Schleiss, Daniel I. Choo

Pediatrics - Infectious Disease

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Recently there has been increased recognition of the importance of congenital cytomegalovirus (CMV) as an etiology of sensorineural hearing loss (SNHL) in newborns. Current data suggest that between 10 and 60% of cases of SNHL in newborns are caused by CMV. This review summarizes current information about the epidemiology and pathogenesis of CMV-induced SNHL, with an emphasis on high-priority areas for future research and potential hypotheses regarding virus and host factors which might play a role in the development and progression of this disease process in newborns with congenital CMV infection.

Original language	English (US)
Pages (from-to)	105-113
Number of pages	9
Journal	Drug Discovery Today: Disease Mechanisms
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.ddmec.2006.02.009
State	Published - 2006

Bibliographical note

Funding Information:
Supported by NIH grants HD38416-01 and HD44864-01, and a grant from the March of Dimes Birth Defects Foundation.

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title = "Mechanisms of congenital cytomegalovirus-induced deafness",

abstract = "Recently there has been increased recognition of the importance of congenital cytomegalovirus (CMV) as an etiology of sensorineural hearing loss (SNHL) in newborns. Current data suggest that between 10 and 60% of cases of SNHL in newborns are caused by CMV. This review summarizes current information about the epidemiology and pathogenesis of CMV-induced SNHL, with an emphasis on high-priority areas for future research and potential hypotheses regarding virus and host factors which might play a role in the development and progression of this disease process in newborns with congenital CMV infection.",

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note = "Funding Information: Supported by NIH grants HD38416-01 and HD44864-01, and a grant from the March of Dimes Birth Defects Foundation.",

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N2 - Recently there has been increased recognition of the importance of congenital cytomegalovirus (CMV) as an etiology of sensorineural hearing loss (SNHL) in newborns. Current data suggest that between 10 and 60% of cases of SNHL in newborns are caused by CMV. This review summarizes current information about the epidemiology and pathogenesis of CMV-induced SNHL, with an emphasis on high-priority areas for future research and potential hypotheses regarding virus and host factors which might play a role in the development and progression of this disease process in newborns with congenital CMV infection.

AB - Recently there has been increased recognition of the importance of congenital cytomegalovirus (CMV) as an etiology of sensorineural hearing loss (SNHL) in newborns. Current data suggest that between 10 and 60% of cases of SNHL in newborns are caused by CMV. This review summarizes current information about the epidemiology and pathogenesis of CMV-induced SNHL, with an emphasis on high-priority areas for future research and potential hypotheses regarding virus and host factors which might play a role in the development and progression of this disease process in newborns with congenital CMV infection.

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Mechanisms of congenital cytomegalovirus-induced deafness

Abstract

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