Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B                         12                          Metabolism: Case Reports and Literature Review

Dolores Mullikin; Nishitha Pillai; Rossana Sanchez; Anne H. O'Donnell- Luria; Amy Kritzer; Leyat Tal; Mohammed Almannai; Gerard T. Berry; Michael J. Gambello; Hong Li; Brett Graham; Lakshmi Srivaths; Vernon Reid Sutton; Amanda Grimes

doi:10.1016/j.jpeds.2018.06.054

Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review

Dolores Mullikin, Nishitha Pillai, Rossana Sanchez, Anne H. O'Donnell- Luria, Amy Kritzer, Leyat Tal, Mohammed Almannai, Gerard T. Berry, Michael J. Gambello, Hong Li, Brett Graham, Lakshmi Srivaths, Vernon Reid Sutton, Amanda Grimes

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We describe 2 children with cobalamin G disease, a disorder of vitamin B ₁₂ metabolism with normal serum B ₁₂ levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.

Original language	English (US)
Pages (from-to)	315-319.e2
Journal	Journal of Pediatrics
Volume	202
DOIs	https://doi.org/10.1016/j.jpeds.2018.06.054
State	Published - Nov 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Cobalamin G disease
Coblamain C disease
hyperhomocysteinemia
megaloblastic anemia
methionine synthase
thrombotic microangiopathy

Access

10.1016/j.jpeds.2018.06.054

OpenUrl availability

Full text

Cite this

Mullikin, D., Pillai, N., Sanchez, R., O'Donnell- Luria, A. H., Kritzer, A., Tal, L., Almannai, M., Berry, G. T., Gambello, M. J., Li, H., Graham, B., Srivaths, L., Sutton, V. R., & Grimes, A. (2018). Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review. Journal of Pediatrics, 202, 315-319.e2. https://doi.org/10.1016/j.jpeds.2018.06.054

Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review. / Mullikin, Dolores; Pillai, Nishitha; Sanchez, Rossana et al.
In: Journal of Pediatrics, Vol. 202, 11.2018, p. 315-319.e2.

Research output: Contribution to journal › Article › peer-review

Mullikin, D, Pillai, N, Sanchez, R, O'Donnell- Luria, AH, Kritzer, A, Tal, L, Almannai, M, Berry, GT, Gambello, MJ, Li, H, Graham, B, Srivaths, L, Sutton, VR & Grimes, A 2018, 'Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B ₁₂ Metabolism: Case Reports and Literature Review', Journal of Pediatrics, vol. 202, pp. 315-319.e2. https://doi.org/10.1016/j.jpeds.2018.06.054

@article{0d3f2705c02b4f1cb1ff124586d56795,

title = "Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B 12 Metabolism: Case Reports and Literature Review",

abstract = " We describe 2 children with cobalamin G disease, a disorder of vitamin B 12 metabolism with normal serum B 12 levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.",

keywords = "Cobalamin G disease, Coblamain C disease, hyperhomocysteinemia, megaloblastic anemia, methionine synthase, thrombotic microangiopathy",

author = "Dolores Mullikin and Nishitha Pillai and Rossana Sanchez and {O'Donnell- Luria}, {Anne H.} and Amy Kritzer and Leyat Tal and Mohammed Almannai and Berry, {Gerard T.} and Gambello, {Michael J.} and Hong Li and Brett Graham and Lakshmi Srivaths and Sutton, {Vernon Reid} and Amanda Grimes",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = nov,

doi = "10.1016/j.jpeds.2018.06.054",

language = "English (US)",

volume = "202",

pages = "315--319.e2",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

}

TY - JOUR

T1 - Megaloblastic Anemia Progressing to Severe Thrombotic Microangiopathy in Patients with Disordered Vitamin B 12 Metabolism

T2 - Case Reports and Literature Review

AU - Mullikin, Dolores

AU - Pillai, Nishitha

AU - Sanchez, Rossana

AU - O'Donnell- Luria, Anne H.

AU - Kritzer, Amy

AU - Tal, Leyat

AU - Almannai, Mohammed

AU - Berry, Gerard T.

AU - Gambello, Michael J.

AU - Li, Hong

AU - Graham, Brett

AU - Srivaths, Lakshmi

AU - Sutton, Vernon Reid

AU - Grimes, Amanda

PY - 2018/11

Y1 - 2018/11

N2 - We describe 2 children with cobalamin G disease, a disorder of vitamin B 12 metabolism with normal serum B 12 levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.

AB - We describe 2 children with cobalamin G disease, a disorder of vitamin B 12 metabolism with normal serum B 12 levels. They presented with megaloblastic anemia progressing rapidly to severe thrombotic microangiopathy. In infants presenting with acute thrombotic microangiopathy, cobalamin disorders should be considered early as diagnosis and targeted treatment can be lifesaving.

KW - Cobalamin G disease

KW - Coblamain C disease

KW - hyperhomocysteinemia

KW - megaloblastic anemia

KW - methionine synthase

KW - thrombotic microangiopathy

UR - http://www.scopus.com/inward/record.url?scp=85050387008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050387008&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2018.06.054

DO - 10.1016/j.jpeds.2018.06.054

M3 - Article

C2 - 30057141

AN - SCOPUS:85050387008

SN - 0022-3476

VL - 202

SP - 315-319.e2

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -