TY - JOUR
T1 - Metabolic and Signaling Roles of Ketone Bodies in Health and Disease
AU - Puchalska, Patrycja
AU - Crawford, Peter A.
N1 - Publisher Copyright:
© 2021 Annual Reviews Inc.. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during states of low carbohydrate availability. Efforts to enhance wellness and ameliorate disease via nutritional, chronobiological, and pharmacological interventions have markedly intensified interest in ketone body metabolism. The two ketone body redox partners, acetoacetate and D-β-hydroxybutyrate, serve distinct metabolic and signaling roles in biological systems. We discuss the pleiotropic roles played by both of these ketones in health and disease. While enthusiasm is warranted, prudent procession through therapeutic applications of ketogenic and ketone therapies is also advised, as a range of metabolic and signaling consequences continue to emerge. Organ-specific and cell-Type-specific effects of ketone bodies are important to consider as prospective therapeutic and wellness applications increase.
AB - Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during states of low carbohydrate availability. Efforts to enhance wellness and ameliorate disease via nutritional, chronobiological, and pharmacological interventions have markedly intensified interest in ketone body metabolism. The two ketone body redox partners, acetoacetate and D-β-hydroxybutyrate, serve distinct metabolic and signaling roles in biological systems. We discuss the pleiotropic roles played by both of these ketones in health and disease. While enthusiasm is warranted, prudent procession through therapeutic applications of ketogenic and ketone therapies is also advised, as a range of metabolic and signaling consequences continue to emerge. Organ-specific and cell-Type-specific effects of ketone bodies are important to consider as prospective therapeutic and wellness applications increase.
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U2 - 10.1146/annurev-nutr-111120-111518
DO - 10.1146/annurev-nutr-111120-111518
M3 - Review article
C2 - 34633859
AN - SCOPUS:85117419035
SN - 0199-9885
VL - 41
SP - 49
EP - 77
JO - Annual review of nutrition
JF - Annual review of nutrition
ER -