Microglial Self-Recognition STINGs in A-T Neurodegeneration

Austin Ferro; Carrie Sheeler; Marija Cvetanovic

doi:10.1016/j.tins.2019.09.005

Microglial Self-Recognition STINGs in A-T Neurodegeneration

Austin Ferro, Carrie Sheeler, Marija Cvetanovic

Neuroscience

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.

Original language	English (US)
Pages (from-to)	753-755
Number of pages	3
Journal	Trends in Neurosciences
Volume	42
Issue number	11
DOIs	https://doi.org/10.1016/j.tins.2019.09.005
State	Published - Nov 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

ATM
NF-κB
ataxia telangiectasia
microglia

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title = "Microglial Self-Recognition STINGs in A-T Neurodegeneration",

abstract = "Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.",

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author = "Austin Ferro and Carrie Sheeler and Marija Cvetanovic",

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year = "2019",

month = nov,

doi = "10.1016/j.tins.2019.09.005",

language = "English (US)",

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T1 - Microglial Self-Recognition STINGs in A-T Neurodegeneration

AU - Ferro, Austin

AU - Sheeler, Carrie

AU - Cvetanovic, Marija

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Y1 - 2019/11

N2 - Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.

AB - Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.

KW - ATM

KW - NF-κB

KW - ataxia telangiectasia

KW - microglia

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DO - 10.1016/j.tins.2019.09.005

M3 - Short survey

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JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 11

ER -

Microglial Self-Recognition STINGs in A-T Neurodegeneration

Abstract

Bibliographical note

Keywords

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