miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

Paige E. Bennett; Lynne Bemis; David A. Norris; Yiqun G. Shellman

doi:10.1152/physiolgenomics.00116.2013

miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

Paige E. Bennett, Lynne Bemis, David A. Norris, Yiqun G. Shellman

Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed.

Original language	English (US)
Pages (from-to)	1049-1059
Number of pages	11
Journal	Physiological genomics
Volume	45
Issue number	22
DOIs	https://doi.org/10.1152/physiolgenomics.00116.2013
State	Published - Nov 15 2013

Keywords

BRAF
MITF
miR-137
miR-18b
miR-214

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/physiolgenomics.00116.2013

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title = "miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma",

abstract = "Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed.",

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AU - Bemis, Lynne

AU - Norris, David A.

AU - Shellman, Yiqun G.

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AB - Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed.

KW - BRAF

KW - MITF

KW - miR-137

KW - miR-18b

KW - miR-214

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miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

Abstract

Keywords

UN SDGs

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