Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation

Frederick R. Adler; Alexander R.A. Anderson; Abhinav Bhushan; Paul Bogdan; Jose Javier Bravo-Cordero; Amy Brock; Yun Chen; Edna Cukierman; Kathleen E. DelGiorno; Gerald V. Denis; Meghan C. Ferrall-Fairbanks; Zev Jordan Gartner; Ronald N. Germain; Deborah M. Gordon; Ginger Hunter; Mohit Kumar Jolly; Loukia Georgiou Karacosta; Karthikeyan Mythreye; Parag Katira; Rajan P. Kulkarni; Matthew L. Kutys; Arthur D. Lander; Ashley M. Laughney; Herbert Levine; Emil Lou; Pedro R. Lowenstein; Kristyn S. Masters; Dana Pe'er; Shelly R. Peyton; Manu O. Platt; Jeremy E. Purvis; Gerald Quon; Jennifer K. Richer; Nicole C. Riddle; Analiz Rodriguez; Joshua C. Snyder; Gregory Lee Szeto; Claire J. Tomlin; Itai Yanai; Ioannis K. Zervantonakis; Hannah Dueck

doi:10.1016/j.cels.2023.03.002

Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation

Frederick R. Adler, Alexander R.A. Anderson, Abhinav Bhushan, Paul Bogdan, Jose Javier Bravo-Cordero, Amy Brock, Yun Chen, Edna Cukierman, Kathleen E. DelGiorno, Gerald V. Denis, Meghan C. Ferrall-Fairbanks, Zev Jordan Gartner, Ronald N. Germain, Deborah M. Gordon, Ginger Hunter, Mohit Kumar Jolly, Loukia Georgiou Karacosta, Karthikeyan Mythreye, Parag Katira, Rajan P. KulkarniMatthew L. Kutys, Arthur D. Lander, Ashley M. Laughney, Herbert Levine, Emil Lou, Pedro R. Lowenstein, Kristyn S. Masters, Dana Pe'er, Shelly R. Peyton, Manu O. Platt, Jeremy E. Purvis, Gerald Quon, Jennifer K. Richer, Nicole C. Riddle, Analiz Rodriguez, Joshua C. Snyder, Gregory Lee Szeto, Claire J. Tomlin, Itai Yanai, Ioannis K. Zervantonakis, Hannah Dueck

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.

Original language	English (US)
Pages (from-to)	252-257
Number of pages	6
Journal	Cell Systems
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.cels.2023.03.002
State	Published - Apr 19 2023

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Publisher Copyright:
© 2023

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Adler, F. R., Anderson, A. R. A., Bhushan, A., Bogdan, P., Bravo-Cordero, J. J., Brock, A., Chen, Y., Cukierman, E., DelGiorno, K. E., Denis, G. V., Ferrall-Fairbanks, M. C., Gartner, Z. J., Germain, R. N., Gordon, D. M., Hunter, G., Jolly, M. K., Karacosta, L. G., Mythreye, K., Katira, P., ... Dueck, H. (2023). Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Systems, 14(4), 252-257. https://doi.org/10.1016/j.cels.2023.03.002

Adler, FR, Anderson, ARA, Bhushan, A, Bogdan, P, Bravo-Cordero, JJ, Brock, A, Chen, Y, Cukierman, E, DelGiorno, KE, Denis, GV, Ferrall-Fairbanks, MC, Gartner, ZJ, Germain, RN, Gordon, DM, Hunter, G, Jolly, MK, Karacosta, LG, Mythreye, K, Katira, P, Kulkarni, RP, Kutys, ML, Lander, AD, Laughney, AM, Levine, H, Lou, E, Lowenstein, PR, Masters, KS, Pe'er, D, Peyton, SR, Platt, MO, Purvis, JE, Quon, G, Richer, JK, Riddle, NC, Rodriguez, A, Snyder, JC, Lee Szeto, G, Tomlin, CJ, Yanai, I, Zervantonakis, IK & Dueck, H 2023, 'Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation', Cell Systems, vol. 14, no. 4, pp. 252-257. https://doi.org/10.1016/j.cels.2023.03.002

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abstract = "Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.",

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AU - Chen, Yun

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AU - Gartner, Zev Jordan

AU - Germain, Ronald N.

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AU - Hunter, Ginger

AU - Jolly, Mohit Kumar

AU - Karacosta, Loukia Georgiou

AU - Mythreye, Karthikeyan

AU - Katira, Parag

AU - Kulkarni, Rajan P.

AU - Kutys, Matthew L.

AU - Lander, Arthur D.

AU - Laughney, Ashley M.

AU - Levine, Herbert

AU - Lou, Emil

AU - Lowenstein, Pedro R.

AU - Masters, Kristyn S.

AU - Pe'er, Dana

AU - Peyton, Shelly R.

AU - Platt, Manu O.

AU - Purvis, Jeremy E.

AU - Quon, Gerald

AU - Richer, Jennifer K.

AU - Riddle, Nicole C.

AU - Rodriguez, Analiz

AU - Snyder, Joshua C.

AU - Lee Szeto, Gregory

AU - Tomlin, Claire J.

AU - Yanai, Itai

AU - Zervantonakis, Ioannis K.

AU - Dueck, Hannah

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Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation

Abstract

Bibliographical note

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