Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Jun Sun; M. Nedim Ince; Clara Abraham; Terrence Barrett; Lisa A. Brenner; Yingzi Cong; Reza Dashti; Pradeep K. Dudeja; David Elliott; Thomas S. Griffith; Peter S. Heeger; Andrew Hoisington; Kaikobad Irani; Tae Kon Kim; Neeraj Kapur; Joseph Leventhal; Mansour Mohamadzadeh; Ece Mutlu; Rodney Newberry; Jonathan U. Peled; Israel Rubinstein; Salyka Sengsayadeth; Chen Sabrina Tan; Xiao Di Tan; Eric Tkaczyk; Jason Wertheim; Zheng Jenny Zhang

doi:10.1080/19490976.2023.2267180

Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Jun Sun, M. Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David Elliott, Thomas S. Griffith, Peter S. Heeger, Andrew Hoisington, Kaikobad Irani, Tae Kon Kim, Neeraj Kapur, Joseph Leventhal, Mansour Mohamadzadeh, Ece Mutlu, Rodney Newberry, Jonathan U. PeledIsrael Rubinstein, Salyka Sengsayadeth, Chen Sabrina Tan, Xiao Di Tan, Eric Tkaczyk, Jason Wertheim, Zheng Jenny Zhang

Urology

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Abstract

The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.

Original language	English (US)
Pages (from-to)	2267180
Number of pages	1
Journal	Gut microbes
Volume	15
Issue number	2
DOIs	https://doi.org/10.1080/19490976.2023.2267180
State	Published - Dec 1 2023

Keywords

IBD
Immunity
graft rejection
graft-versus-host disease
gut microbiome
gut-brain-axis
infection
micronutrition
mitochondria
oral microbiome
posttraumatic stress disorder
virome
vitamin

PubMed: MeSH publication types

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/19490976.2023.2267180

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Sun, J., Ince, M. N., Abraham, C., Barrett, T., Brenner, L. A., Cong, Y., Dashti, R., Dudeja, P. K., Elliott, D., Griffith, T. S., Heeger, P. S., Hoisington, A., Irani, K., Kim, T. K., Kapur, N., Leventhal, J., Mohamadzadeh, M., Mutlu, E., Newberry, R., ... Zhang, Z. J. (2023). Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting. Gut microbes, 15(2), 2267180. https://doi.org/10.1080/19490976.2023.2267180

Sun, J, Ince, MN, Abraham, C, Barrett, T, Brenner, LA, Cong, Y, Dashti, R, Dudeja, PK, Elliott, D, Griffith, TS, Heeger, PS, Hoisington, A, Irani, K, Kim, TK, Kapur, N, Leventhal, J, Mohamadzadeh, M, Mutlu, E, Newberry, R, Peled, JU, Rubinstein, I, Sengsayadeth, S, Tan, CS, Tan, XD, Tkaczyk, E, Wertheim, J & Zhang, ZJ 2023, 'Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting', Gut microbes, vol. 15, no. 2, pp. 2267180. https://doi.org/10.1080/19490976.2023.2267180

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KW - oral microbiome

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KW - virome

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Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting

Abstract

Keywords

PubMed: MeSH publication types

UN SDGs

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