MTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression

TY - JOUR

T1 - MTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression

AU - Guo, F.

AU - Li, J.

AU - Zhang, S.

AU - Du, W.

AU - Amarachintha, S.

AU - Sipple, J.

AU - Phelan, J.

AU - Grimes, H. L.

AU - Zheng, Y.

AU - Pang, Q.

N1 - Funding Information: We thank Dr Alan D’Andrea (Harvard Medical School) for the pMMP-Puro and pMMP-FANCD2 retroviral vectors, Dr Xiaoli Li and Jonathan Schick for technical assistance, the Vector Core of the Cincinnati Children’s Research Foundation (Cincinnati Children’s Hospital Medical Center) for the preparation of retroviruses, the Comprehensive Mouse and Cancer Core of the Cincinnati Children’s Research Foundation (Cincinnati Children’s Hospital Medical Center) for bone marrow transplantation service and Leesa Sampson for data analysis. This investigation was supported by NIH grants R01 HL076712, R01 CA157537, P30 DK090971 and T32 HL091805. QP is supported by a Leukemia and Lymphoma Scholar award. WD is supported by a NIH T32 training grant.

PY - 2014

Y1 - 2014

UR - http://www.scopus.com/inward/record.url?scp=84891847714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891847714&partnerID=8YFLogxK

U2 - 10.1038/leu.2013.215

DO - 10.1038/leu.2013.215

M3 - Letter

C2 - 23852546

AN - SCOPUS:84891847714

SN - 0887-6924

VL - 28

SP - 203

EP - 206

JO - Leukemia

JF - Leukemia

IS - 1

ER -