Abstract
Ultrafast magic angle spinning (MAS) technology and 1H detection have dramatically enhanced the sensitivity of solid-state NMR (ssNMR) spectroscopy of biopolymers. We previously showed that, when combined with polarization optimized experiments (POE), these advancements enable the simultaneous acquisition of multi-dimensional 1H- or 13C-detected experiments using a single receiver. Here, we propose a new sub-class within the POE family, namely HC-DUMAS, HC-MEIOSIS, and HC-MAeSTOSO, that utilize dual receiver technology for the simultaneous detection of 1H and 13C nuclei. We also expand this approach to record 1H-, 13C-, and 15N-detected homonuclear 2D spectra simultaneously using three independent receivers. The combination of POE and multi-receiver technology will further shorten the total experimental time of ssNMR experiments for biological solids.
Original language | English (US) |
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Pages (from-to) | 267-285 |
Number of pages | 19 |
Journal | Journal of biomolecular NMR |
Volume | 74 |
Issue number | 4-5 |
DOIs | |
State | Published - May 1 2020 |
Bibliographical note
Publisher Copyright:© 2020, Springer Nature B.V.
Keywords
- HC-DUMAS
- HC-MAeSTOSO
- HC-MEIOSIS
- Multi-acquisition
- Multi-receiver
- Polarization optimized experiments (POE)
- SIM-CP
- Solid-state NMR
- Ultra-fast magic angle spinning