Multifunctional chitosan nanoparticles for tumor imaging and therapy

Ji Young Yhee; Heebeom Koo; Dong Eun Lee; Kuiwon Choi; Ick Chan Kwon; Kwangmeyung Kim

doi:10.1007/12_2011_119

Multifunctional chitosan nanoparticles for tumor imaging and therapy

Ji Young Yhee, Heebeom Koo, Dong Eun Lee, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim

Research output: Chapter in Book/Report/Conference proceeding › Chapter

26 Scopus citations

Abstract

Chitosan and its derivatives have been widely used for various biomedical applications because of their unique chemical and biological characters. The amine groups in the backbone of chitosan allow chemical modification to change the physical properties of chitosan. Based on hydrophobic or charge interactions with this chitosan polymer backbone, stable self-assembled nanoparticles can be fabricated in aqueous condition. These nanosized structures enable intravenous injection and show large accumulation in tumor tissue, indicating great potential in imaging and drug delivery. The main objective of this review is to introduce various chitosan nanoparticles and their recent applications for tumor diagnosis and therapy.

Original language	English (US)
Title of host publication	Chitosan for Biomaterials I
Editors	R. Jayakumar, Riccardo Muzzarelli, M. Prabaharan
Pages	139-162
Number of pages	24
Edition	1
DOIs	https://doi.org/10.1007/12_2011_119
State	Published - 2011
Externally published	Yes

Publication series

Name	Advances in Polymer Science
Number	1
Volume	243
ISSN (Print)	0065-3195

Bibliographical note

Funding Information:
Financial support was given by the Fusion Technology Project (2009-0081876) of MEST, and the Intramural Research Program of KIST.

Keywords

Chitosan
Molecular imaging
Nanoparticle
Tumor

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title = "Multifunctional chitosan nanoparticles for tumor imaging and therapy",

abstract = "Chitosan and its derivatives have been widely used for various biomedical applications because of their unique chemical and biological characters. The amine groups in the backbone of chitosan allow chemical modification to change the physical properties of chitosan. Based on hydrophobic or charge interactions with this chitosan polymer backbone, stable self-assembled nanoparticles can be fabricated in aqueous condition. These nanosized structures enable intravenous injection and show large accumulation in tumor tissue, indicating great potential in imaging and drug delivery. The main objective of this review is to introduce various chitosan nanoparticles and their recent applications for tumor diagnosis and therapy.",

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AU - Yhee, Ji Young

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AU - Lee, Dong Eun

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

N1 - Funding Information: Financial support was given by the Fusion Technology Project (2009-0081876) of MEST, and the Intramural Research Program of KIST.

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AB - Chitosan and its derivatives have been widely used for various biomedical applications because of their unique chemical and biological characters. The amine groups in the backbone of chitosan allow chemical modification to change the physical properties of chitosan. Based on hydrophobic or charge interactions with this chitosan polymer backbone, stable self-assembled nanoparticles can be fabricated in aqueous condition. These nanosized structures enable intravenous injection and show large accumulation in tumor tissue, indicating great potential in imaging and drug delivery. The main objective of this review is to introduce various chitosan nanoparticles and their recent applications for tumor diagnosis and therapy.

KW - Chitosan

KW - Molecular imaging

KW - Nanoparticle

KW - Tumor

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Multifunctional chitosan nanoparticles for tumor imaging and therapy

Abstract

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Bibliographical note

Keywords

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