Muscimol induces gastric acid secretion after central administration

Allen S. Levine; John E. Morley; Julie Kneip; Martha Grace; Stephen E. Silvis

doi:10.1016/0006-8993(81)90770-8

Muscimol induces gastric acid secretion after central administration

Allen S. Levine, John E. Morley, Julie Kneip, Martha Grace, Stephen E. Silvis

Medicine - Administration

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Abstract

Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occured in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of d-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric accretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.

Original language	English (US)
Pages (from-to)	270-274
Number of pages	5
Journal	Brain Research
Volume	229
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)90770-8
State	Published - Dec 14 1981

Keywords

GABA
bombesin
calcitonin
enkephalin
gamma amino butyric acid
gastric acid
muscimol

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title = "Muscimol induces gastric acid secretion after central administration",

abstract = "Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occured in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of d-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric accretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.",

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AU - Morley, John E.

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AU - Grace, Martha

AU - Silvis, Stephen E.

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AB - Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occured in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of d-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric accretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.

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KW - calcitonin

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Muscimol induces gastric acid secretion after central administration

Abstract

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