Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

Joel C. Eissenberg; Tharappel C. James; Dawn M. Foster-Hartnett; Thomas Hartnett; Vivian Ngan; Sarah C.R. Elgin

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

Joel C. Eissenberg, Tharappel C. James, Dawn M. Foster-Hartnett, Thomas Hartnett, Vivian Ngan, Sarah C.R. Elgin

Research output: Contribution to journal › Article › peer-review

Abstract

We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

Original language	English (US)
Pages (from-to)	9923-9927
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	87
Issue number	24
State	Published - 1990
Externally published	Yes

Keywords

Aberrant pre-mRNA splicing
Dominant suppression of heterochromatic position effects
Heterochromatin-associated protein

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Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. / Eissenberg, Joel C.; James, Tharappel C.; Foster-Hartnett, Dawn M. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 24, 1990, p. 9923-9927.

Research output: Contribution to journal › Article › peer-review

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AU - Hartnett, Thomas

AU - Ngan, Vivian

AU - Elgin, Sarah C.R.

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KW - Heterochromatin-associated protein

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Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

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