N-Pyridylimidates as Traceless Acyl Equivalents for Directed C-O Bond Functionalization

Steven J. Underwood; Christopher J. Douglas

doi:10.1021/acs.orglett.2c03961

N-Pyridylimidates as Traceless Acyl Equivalents for Directed C-O Bond Functionalization

Steven J. Underwood, Christopher J. Douglas

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Directing groups are a common strategy to target traditionally inert bonds, with an easily removable directing group being ideal. Herein we disclose our method for rhodium-catalyzed C-O bond functionalization of N-pyridylimidates using a recyclable and traceless amine directing group. In addition to the substrate scope, we discuss the behavior of this class of compounds and how that behavior affects their reactivity.

Original language	English (US)
Pages (from-to)	146-151
Number of pages	6
Journal	Organic Letters
Volume	25
Issue number	1
DOIs	https://doi.org/10.1021/acs.orglett.2c03961
State	Published - Jan 13 2023

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© 2022 American Chemical Society.

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N-Pyridylimidates as Traceless Acyl Equivalents for Directed C-O Bond Functionalization

Abstract

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