Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

Xiaoli Wang; Dandan Miao; Xiaoyu Liang; Jiayi Liang; Chao Zhang; Jing Yang; Deling Kong; Chun Wang; Hongfan Sun

doi:10.1039/c6bm00915h

Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

Xiaoli Wang, Dandan Miao, Xiaoyu Liang, Jiayi Liang, Chao Zhang, Jing Yang, Deling Kong, Chun Wang, Hongfan Sun

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A novel bone-targeted delivery systems based on nanocapsules was developed utilizing a Zeolitic Imidazolate Framework (ZIF-8) as a template and catechol-modified gelatin as wall material. A targeting ligand was facilely conjugated on the surface of nanocapsules. Simvastatin was encapsulated within the nanocapsules with a loading of 37.9%. Hydroxyapatite binding and in vivo biodistribution of the drug-loaded nanocapsules were investigated.

Original language	English (US)
Pages (from-to)	658-662
Number of pages	5
Journal	Biomaterials science
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/c6bm00915h
State	Published - Apr 2017

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© 2017 The Royal Society of Chemistry.

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AU - Wang, Xiaoli

AU - Miao, Dandan

AU - Liang, Xiaoyu

AU - Liang, Jiayi

AU - Zhang, Chao

AU - Yang, Jing

AU - Kong, Deling

AU - Wang, Chun

AU - Sun, Hongfan

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Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery

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