Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region

Michelle M. Riehle; Kyriacos Markianos; Oumou Niaré; Jiannong Xu; Jun Li; Abdoulaya M. Touré; Balco Podiougou; Frederick Oduol; Sory Diawara; Mouctar Diallo; Boubacar Coulibaly; Ahmad Ouatara; Leonid Kruglyak; Sékou F. Traoré; Kenneth D. Vernick

doi:10.1126/science.1124153

Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region

Michelle M. Riehle, Kyriacos Markianos, Oumou Niaré, Jiannong Xu, Jun Li, Abdoulaya M. Touré, Balco Podiougou, Frederick Oduol, Sory Diawara, Mouctar Diallo, Boubacar Coulibaly, Ahmad Ouatara, Leonid Kruglyak, Sékou F. Traoré, Kenneth D. Vernick

Microbiology

Research output: Contribution to journal › Review article › peer-review

222 Scopus citations

Abstract

We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.

Original language	English (US)
Pages (from-to)	577-579
Number of pages	3
Journal	Science
Volume	312
Issue number	5773
DOIs	https://doi.org/10.1126/science.1124153
State	Published - Apr 28 2006

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Riehle, M. M., Markianos, K., Niaré, O., Xu, J., Li, J., Touré, A. M., Podiougou, B., Oduol, F., Diawara, S., Diallo, M., Coulibaly, B., Ouatara, A., Kruglyak, L., Traoré, S. F., & Vernick, K. D. (2006). Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science, 312(5773), 577-579. https://doi.org/10.1126/science.1124153

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abstract = "We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.",

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AU - Riehle, Michelle M.

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AU - Xu, Jiannong

AU - Li, Jun

AU - Touré, Abdoulaya M.

AU - Podiougou, Balco

AU - Oduol, Frederick

AU - Diawara, Sory

AU - Diallo, Mouctar

AU - Coulibaly, Boubacar

AU - Ouatara, Ahmad

AU - Kruglyak, Leonid

AU - Traoré, Sékou F.

AU - Vernick, Kenneth D.

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N2 - We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.

AB - We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.

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Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region

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