TY - JOUR
T1 - Natural products for dental caries prevention
AU - Badria, Farid A.
AU - Zidan, Omar A.
PY - 2004/9
Y1 - 2004/9
N2 - Selected natural compounds were evaluated for their effects on dental caries due to different strains of Streptococcus mutans bacteria. Out of 39 tested compounds, four (catechol, emetine, quinine, and flavone) showed potent inhibitory activity on different strains of S. mutans at 6.25 μg/mL or less with inhibition of adherence <50%, two compounds (5,7-di-hydroxy-4′- methoxy isoflavone and ellagic acid) exhibited a moderate inhibitory effect at 12.5 μg/mL with inhibition to adherence <50%, and 12 compounds exhibited weak antibacterial activity at 125 μg/mL or more with inhibition of adherence <25%. These compounds represent three major classes of natural products: tannins, alkaloids, and flavonoids. Further study for possible application of these compounds as inhibitors for dental caries is underway.
AB - Selected natural compounds were evaluated for their effects on dental caries due to different strains of Streptococcus mutans bacteria. Out of 39 tested compounds, four (catechol, emetine, quinine, and flavone) showed potent inhibitory activity on different strains of S. mutans at 6.25 μg/mL or less with inhibition of adherence <50%, two compounds (5,7-di-hydroxy-4′- methoxy isoflavone and ellagic acid) exhibited a moderate inhibitory effect at 12.5 μg/mL with inhibition to adherence <50%, and 12 compounds exhibited weak antibacterial activity at 125 μg/mL or more with inhibition of adherence <25%. These compounds represent three major classes of natural products: tannins, alkaloids, and flavonoids. Further study for possible application of these compounds as inhibitors for dental caries is underway.
KW - Dental caries
KW - Natural products
KW - Streptococcus mutans
UR - http://www.scopus.com/inward/record.url?scp=4644236959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644236959&partnerID=8YFLogxK
U2 - 10.1089/jmf.2004.7.381
DO - 10.1089/jmf.2004.7.381
M3 - Article
C2 - 15383236
AN - SCOPUS:4644236959
SN - 1096-620X
VL - 7
SP - 381
EP - 384
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 3
ER -