Nephroprotective action of peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats

Mohammad Aslam; Shiekh Tanveer Ahmad; Rameshver Dayal; Kalim Javid; Sadiq Umar; Asia Asiaf; Sana Nafees; Jalal Uddin Bhat; Arjumand Wani; Mohammad Samim; Surender Singh

Nephroprotective action of peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats

Mohammad Aslam, Shiekh Tanveer Ahmad, Rameshver Dayal, Kalim Javid, Sadiq Umar, Asia Asiaf, Sana Nafees, Jalal Uddin Bhat, Arjumand Wani, Mohammad Samim, Surender Singh

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Abstract

Cadmium is a known industrial pollutant which accumulates in the kidney and its exposure leads to the production of reactive oxygen species (ROS). The present study was carried out to evaluate the protective effects of Peucedanum grande against CdCl ₂ induced renal toxicity in Wistar rats. Wistar rats were subjected to oral pre-treatment of P. grande (60 and 120 mg/kg b.wt) against the renal toxicity induced by administration of CdCl ₂ (3mg/kg b.wt). Efficacy of P. grande against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities and histopathological changes. P. grande pretreatment prevented deteriorative effects induced by CdCl ₂ through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological changes against CdCl ₂ administration.

Original language	English (US)
Pages (from-to)	444-452
Number of pages	9
Journal	EXCLI Journal
Volume	11
State	Published - 2012
Externally published	Yes

Keywords

Cadmium chloride
Nephrotoxicity
Peucedanum grande
ROS

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title = "Nephroprotective action of peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats",

abstract = "Cadmium is a known industrial pollutant which accumulates in the kidney and its exposure leads to the production of reactive oxygen species (ROS). The present study was carried out to evaluate the protective effects of Peucedanum grande against CdCl 2 induced renal toxicity in Wistar rats. Wistar rats were subjected to oral pre-treatment of P. grande (60 and 120 mg/kg b.wt) against the renal toxicity induced by administration of CdCl 2 (3mg/kg b.wt). Efficacy of P. grande against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities and histopathological changes. P. grande pretreatment prevented deteriorative effects induced by CdCl 2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological changes against CdCl 2 administration.",

keywords = "Cadmium chloride, Nephrotoxicity, Peucedanum grande, ROS",

author = "Mohammad Aslam and Ahmad, {Shiekh Tanveer} and Rameshver Dayal and Kalim Javid and Sadiq Umar and Asia Asiaf and Sana Nafees and Bhat, {Jalal Uddin} and Arjumand Wani and Mohammad Samim and Surender Singh",

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T1 - Nephroprotective action of peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats

AU - Aslam, Mohammad

AU - Ahmad, Shiekh Tanveer

AU - Dayal, Rameshver

AU - Javid, Kalim

AU - Umar, Sadiq

AU - Asiaf, Asia

AU - Nafees, Sana

AU - Bhat, Jalal Uddin

AU - Wani, Arjumand

AU - Samim, Mohammad

AU - Singh, Surender

PY - 2012

Y1 - 2012

N2 - Cadmium is a known industrial pollutant which accumulates in the kidney and its exposure leads to the production of reactive oxygen species (ROS). The present study was carried out to evaluate the protective effects of Peucedanum grande against CdCl 2 induced renal toxicity in Wistar rats. Wistar rats were subjected to oral pre-treatment of P. grande (60 and 120 mg/kg b.wt) against the renal toxicity induced by administration of CdCl 2 (3mg/kg b.wt). Efficacy of P. grande against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities and histopathological changes. P. grande pretreatment prevented deteriorative effects induced by CdCl 2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological changes against CdCl 2 administration.

AB - Cadmium is a known industrial pollutant which accumulates in the kidney and its exposure leads to the production of reactive oxygen species (ROS). The present study was carried out to evaluate the protective effects of Peucedanum grande against CdCl 2 induced renal toxicity in Wistar rats. Wistar rats were subjected to oral pre-treatment of P. grande (60 and 120 mg/kg b.wt) against the renal toxicity induced by administration of CdCl 2 (3mg/kg b.wt). Efficacy of P. grande against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities and histopathological changes. P. grande pretreatment prevented deteriorative effects induced by CdCl 2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological changes against CdCl 2 administration.

KW - Cadmium chloride

KW - Nephrotoxicity

KW - Peucedanum grande

KW - ROS

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M3 - Article

AN - SCOPUS:84867618090

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VL - 11

SP - 444

EP - 452

JO - EXCLI Journal

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ER -

Nephroprotective action of peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats

Abstract

Keywords

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