Nephrotoxicity of Cyclosporine

B. D. Kahan; C. t.Van Buren; C. A. Wideman; D. A. Cooley; O. H. Frazier; Uwe J. Hesse; David E.r. Sutherland; S. Michael Mauer; John S. Najarian; Robert M. Merion; David J.g. White; Robert W. Griffith; Peter A. Woodbridge; Joe C. Rutledge; Bryan D. Myers; Jon Ross; Lynn Newton; John Luetscher; Mark Perlroth

doi:10.1056/NEJM198501033120112

Nephrotoxicity of Cyclosporine

B. D. Kahan, C. t.Van Buren, C. A. Wideman, D. A. Cooley, O. H. Frazier, Uwe J. Hesse, David E.r. Sutherland, S. Michael Mauer, John S. Najarian, Robert M. Merion, David J.g. White, Robert W. Griffith, Peter A. Woodbridge, Joe C. Rutledge, Bryan D. Myers, Jon Ross, Lynn Newton, John Luetscher, Mark Perlroth

Pediatrics - Nephrology

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

To the Editor: In the September 13 issue of the Journal, Myers and co-workers¹cite our work² to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels³ state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.

Original language	English (US)
Pages (from-to)	48-50
Number of pages	3
Journal	New England Journal of Medicine
Volume	312
Issue number	1
DOIs	https://doi.org/10.1056/NEJM198501033120112
State	Published - Jan 3 1985

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Kahan, B. D., Buren, C. T. V., Wideman, C. A., Cooley, D. A., Frazier, O. H., Hesse, U. J., Sutherland, D. E. R., Mauer, S. M., Najarian, J. S., Merion, R. M., White, D. J. G., Griffith, R. W., Woodbridge, P. A., Rutledge, J. C., Myers, B. D., Ross, J., Newton, L., Luetscher, J., & Perlroth, M. (1985). Nephrotoxicity of Cyclosporine. New England Journal of Medicine, 312(1), 48-50. https://doi.org/10.1056/NEJM198501033120112

Kahan, BD, Buren, CTV, Wideman, CA, Cooley, DA, Frazier, OH, Hesse, UJ, Sutherland, DER, Mauer, SM, Najarian, JS, Merion, RM, White, DJG, Griffith, RW, Woodbridge, PA, Rutledge, JC, Myers, BD, Ross, J, Newton, L, Luetscher, J & Perlroth, M 1985, 'Nephrotoxicity of Cyclosporine', New England Journal of Medicine, vol. 312, no. 1, pp. 48-50. https://doi.org/10.1056/NEJM198501033120112

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abstract = "To the Editor: In the September 13 issue of the Journal, Myers and co-workers1cite our work2 to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels3 state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.",

author = "Kahan, {B. D.} and Buren, {C. t.Van} and Wideman, {C. A.} and Cooley, {D. A.} and Frazier, {O. H.} and Hesse, {Uwe J.} and Sutherland, {David E.r.} and Mauer, {S. Michael} and Najarian, {John S.} and Merion, {Robert M.} and White, {David J.g.} and Griffith, {Robert W.} and Woodbridge, {Peter A.} and Rutledge, {Joe C.} and Myers, {Bryan D.} and Jon Ross and Lynn Newton and John Luetscher and Mark Perlroth",

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AU - Kahan, B. D.

AU - Buren, C. t.Van

AU - Wideman, C. A.

AU - Cooley, D. A.

AU - Frazier, O. H.

AU - Hesse, Uwe J.

AU - Sutherland, David E.r.

AU - Mauer, S. Michael

AU - Najarian, John S.

AU - Merion, Robert M.

AU - White, David J.g.

AU - Griffith, Robert W.

AU - Woodbridge, Peter A.

AU - Rutledge, Joe C.

AU - Myers, Bryan D.

AU - Ross, Jon

AU - Newton, Lynn

AU - Luetscher, John

AU - Perlroth, Mark

PY - 1985/1/3

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N2 - To the Editor: In the September 13 issue of the Journal, Myers and co-workers1cite our work2 to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels3 state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.

AB - To the Editor: In the September 13 issue of the Journal, Myers and co-workers1cite our work2 to support the statement that “the dose was reduced thereafter to maintain trough plasma levels of immunoassayable cyclosporine slightly above a putative immunosuppressive threshold of 200 ng per milliliter.” In fact, both the cited article and the previous, more specific publication addressing trough levels3 state that 200 ng per milliliter represents the threshold for nephrotoxicity. Recipients of renal allografts who have abnormal renal function due to drug-induced nephrotoxicity generally have trough levels above 200 ng per milliliter as determined in serum by.

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

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Nephrotoxicity of Cyclosporine

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