Abstract
Cognitive control, the ability to rapidly shift one's attention and behavioral strategy in response to environmental changes, is often compromised across psychiatric disorders. One of the well-validated behavioral paradigms for tapping into the cognitive control circuits is a cognitive interference task, where subjects must suppress a natural response to follow a less intuitive rule. Slower response times on these tasks indicate difficulty exerting control to overcome response conflict. Conflict evokes robust electrophysiological signatures, such as theta (4-8 Hz) oscillations in the prefrontal cortex (PFC). However, the underlying neural mechanisms of conflict-evoked theta oscillations in the PFC are not clear. The objective of this work is to use a neural mass model (NMM) to find feasible cortical networks generating theta oscillations during conflict processing in human subjects. We used intracranial EEG (iEEG) recorded from dorsolateral PFC (dIPFC) and lateral temporal lobe (LTL) of human subjects with intractable epilepsy undergoing invasive monitoring, while they performed a multi-source interference task (MSIT). We used a dynamic causal modeling (DCM) framework to simulate dIPFC-LTL theta using a Jansen-Rit NMM. We found significant evidence for an LTL input into the dlPFC during the initial 500 ms of conflict processing compared to a bidirectional connection between the dlPFC and LTL. We conclude that a neural mass modeling framework can be used to elucidate candidate mechanisms of neural oscillations underlying conflict resolution in human subjects. Clinical Relevance - This can be used to find feasible target mechanisms for designing therapy in patients with compromised cognitive control.
Original language | English (US) |
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Title of host publication | 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 2937-2940 |
Number of pages | 4 |
ISBN (Electronic) | 9781728127828 |
DOIs | |
State | Published - 2022 |
Event | 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 - Glasgow, United Kingdom Duration: Jul 11 2022 → Jul 15 2022 |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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Volume | 2022-July |
ISSN (Print) | 1557-170X |
Conference
Conference | 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022 |
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Country/Territory | United Kingdom |
City | Glasgow |
Period | 7/11/22 → 7/15/22 |
Bibliographical note
Publisher Copyright:© 2022 IEEE.
PubMed: MeSH publication types
- Journal Article
- Research Support, U.S. Gov't, Non-P.H.S.
- Research Support, Non-U.S. Gov't