TY - JOUR
T1 - Neuroendocrine responses to hypoglycemia
AU - Tesfaye, Nolawit
AU - Seaquist, Elizabeth R.
PY - 2010/11
Y1 - 2010/11
N2 - The counterregulatory response to hypoglycemia is a complex and well-coordinated process. As blood glucose concentration declines, peripheral and central glucose sensors relay this information to central integrative centers to coordinate neuroendocrine, autonomic, and behavioral responses and avert the progression of hypoglycemia. Diabetes, both type 1 and type 2, can perturb these counterregulatory responses. Moreover, defective counterregulation in the setting of diabetes can progress to hypoglycemia unawareness. While the mechanisms that underlie the development of hypoglycemia unawareness are not completely known, possible causes include altered sensing of hypoglycemia by the brain and/or impaired coordination of responses to hypoglycemia. Further study is needed to better understand the intricacies of the counterregulatory response and the mechanisms contributing to the development of hypoglycemia unawareness.
AB - The counterregulatory response to hypoglycemia is a complex and well-coordinated process. As blood glucose concentration declines, peripheral and central glucose sensors relay this information to central integrative centers to coordinate neuroendocrine, autonomic, and behavioral responses and avert the progression of hypoglycemia. Diabetes, both type 1 and type 2, can perturb these counterregulatory responses. Moreover, defective counterregulation in the setting of diabetes can progress to hypoglycemia unawareness. While the mechanisms that underlie the development of hypoglycemia unawareness are not completely known, possible causes include altered sensing of hypoglycemia by the brain and/or impaired coordination of responses to hypoglycemia. Further study is needed to better understand the intricacies of the counterregulatory response and the mechanisms contributing to the development of hypoglycemia unawareness.
KW - Counterregulation
KW - Diabetes
KW - Hypoglycemia
KW - Hypoglycemia unawareness
UR - http://www.scopus.com/inward/record.url?scp=78649475205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649475205&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2010.05820.x
DO - 10.1111/j.1749-6632.2010.05820.x
M3 - Article
C2 - 21039590
AN - SCOPUS:78649475205
SN - 0077-8923
VL - 1212
SP - 12
EP - 28
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -