Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Joao Prola Netto; Jeffrey Iliff; Danica Stanimirovic; Kenneth A. Krohn; Bronwyn Hamilton; Csanad Varallyay; Seymur Gahramanov; Heike Daldrup-Link; Christopher D'Esterre; Berislav Zlokovic; Haris Sair; Yueh Lee; Saeid Taheri; Rajan Jain; Ashok Panigrahy; Daniel S. Reich; Lester R. Drewes; Mauricio Castillo; Edward A. Neuwelt

doi:10.1093/neuros/nyx357

Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Joao Prola Netto, Jeffrey Iliff, Danica Stanimirovic, Kenneth A. Krohn, Bronwyn Hamilton, Csanad Varallyay, Seymur Gahramanov, Heike Daldrup-Link, Christopher D'Esterre, Berislav Zlokovic, Haris Sair, Yueh Lee, Saeid Taheri, Rajan Jain, Ashok Panigrahy, Daniel S. Reich, Lester R. Drewes, Mauricio Castillo, Edward A. Neuwelt

Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.

Original language	English (US)
Pages (from-to)	770-780
Number of pages	11
Journal	Neurosurgery
Volume	82
Issue number	6
DOIs	https://doi.org/10.1093/neuros/nyx357
State	Published - Jun 1 2018

Bibliographical note

Funding Information:
This work was supported in part by National Institute of Health grants R13 CA086959, NS053468, and CA137488-15S1, in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E, and by the Walter S. and Lucienne Driskill Foundation, all to EAN. Funding by P01 CA042045 went to KAK. HED was funded by R01 HD081123A and R21 CA176519. HS received funding support from the RSNA Carestream Health Research Scholar Grant and ImmunArray. DSR is funded by the Intramural Research Programs of the NINDS and has received research funding from Vertex Pharmaceuticals and the Myelin Repair Foundation. The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article.

Funding Information:
This work was supported in part by National Institute of Health grants R13 CA086959, NS053468, and CA137488-15S1, in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E, and by the Walter S. and Lucienne Driskill Foundation, all to EAN. Funding by P01 CA042045 went to KAK. HED was funded by R01 HD081123A and R21 CA176519.

Publisher Copyright:
© 2017 by the Congress of Neurological Surgeons.

Keywords

Blood-brain barrier
Imaging
Neurovascular unit

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Netto, J. P., Iliff, J., Stanimirovic, D., Krohn, K. A., Hamilton, B., Varallyay, C., Gahramanov, S., Daldrup-Link, H., D'Esterre, C., Zlokovic, B., Sair, H., Lee, Y., Taheri, S., Jain, R., Panigrahy, A., Reich, D. S., Drewes, L. R., Castillo, M., & Neuwelt, E. A. (2018). Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol. Neurosurgery, 82(6), 770-780. https://doi.org/10.1093/neuros/nyx357

Netto, JP, Iliff, J, Stanimirovic, D, Krohn, KA, Hamilton, B, Varallyay, C, Gahramanov, S, Daldrup-Link, H, D'Esterre, C, Zlokovic, B, Sair, H, Lee, Y, Taheri, S, Jain, R, Panigrahy, A, Reich, DS, Drewes, LR, Castillo, M & Neuwelt, EA 2018, 'Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol', Neurosurgery, vol. 82, no. 6, pp. 770-780. https://doi.org/10.1093/neuros/nyx357

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abstract = "Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.",

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author = "Netto, {Joao Prola} and Jeffrey Iliff and Danica Stanimirovic and Krohn, {Kenneth A.} and Bronwyn Hamilton and Csanad Varallyay and Seymur Gahramanov and Heike Daldrup-Link and Christopher D'Esterre and Berislav Zlokovic and Haris Sair and Yueh Lee and Saeid Taheri and Rajan Jain and Ashok Panigrahy and Reich, {Daniel S.} and Drewes, {Lester R.} and Mauricio Castillo and Neuwelt, {Edward A.}",

note = "Funding Information: This work was supported in part by National Institute of Health grants R13 CA086959, NS053468, and CA137488-15S1, in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E, and by the Walter S. and Lucienne Driskill Foundation, all to EAN. Funding by P01 CA042045 went to KAK. HED was funded by R01 HD081123A and R21 CA176519. HS received funding support from the RSNA Carestream Health Research Scholar Grant and ImmunArray. DSR is funded by the Intramural Research Programs of the NINDS and has received research funding from Vertex Pharmaceuticals and the Myelin Repair Foundation. The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article. Funding Information: This work was supported in part by National Institute of Health grants R13 CA086959, NS053468, and CA137488-15S1, in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E, and by the Walter S. and Lucienne Driskill Foundation, all to EAN. Funding by P01 CA042045 went to KAK. HED was funded by R01 HD081123A and R21 CA176519. Publisher Copyright: {\textcopyright} 2017 by the Congress of Neurological Surgeons.",

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AU - Netto, Joao Prola

AU - Iliff, Jeffrey

AU - Stanimirovic, Danica

AU - Krohn, Kenneth A.

AU - Hamilton, Bronwyn

AU - Varallyay, Csanad

AU - Gahramanov, Seymur

AU - Daldrup-Link, Heike

AU - D'Esterre, Christopher

AU - Zlokovic, Berislav

AU - Sair, Haris

AU - Lee, Yueh

AU - Taheri, Saeid

AU - Jain, Rajan

AU - Panigrahy, Ashok

AU - Reich, Daniel S.

AU - Drewes, Lester R.

AU - Castillo, Mauricio

AU - Neuwelt, Edward A.

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AB - Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.

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Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Abstract

Bibliographical note

Keywords

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