New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

Frank Joy Ankudey; Paul Kiprof; Emily R. Stromquist; Chee Chang Leng

doi:10.1055/s-2008-1074506

New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

Frank Joy Ankudey, Paul Kiprof, Emily R. Stromquist, Chee Chang Leng

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

Original language	English (US)
Pages (from-to)	555-559
Number of pages	5
Journal	Planta Medica
Volume	74
Issue number	5
DOIs	https://doi.org/10.1055/s-2008-1074506
State	Published - Apr 2008

Keywords

Bromotyrosine alkaloids
Hyphae formation inhibition
Marine sponge, Aplysinella sp.
Protein phosphorylation inhibitors

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title = "New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.",

abstract = "A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.",

keywords = "Bromotyrosine alkaloids, Hyphae formation inhibition, Marine sponge, Aplysinella sp., Protein phosphorylation inhibitors",

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doi = "10.1055/s-2008-1074506",

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AU - Kiprof, Paul

AU - Stromquist, Emily R.

AU - Leng, Chee Chang

PY - 2008/4

Y1 - 2008/4

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AB - A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

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KW - Hyphae formation inhibition

KW - Marine sponge, Aplysinella sp.

KW - Protein phosphorylation inhibitors

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New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

Abstract

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