Abstract
Nitric oxide (NO) is an important second messenger involved in numerous biological processes, but how it regulates gene expression is not well understood. In this issue of Genes & Development, Cáceres and colleagues (pp. 1476-1485) report a critical requirement of NO as a direct regulator of gene expression through its binding to a heme-containing nuclear receptor in Drosophila. This may be an anciently evolved mechanism to coordinate behavior and metabolism during animal development.
Original language | English (US) |
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Pages (from-to) | 1459-1463 |
Number of pages | 5 |
Journal | Genes and Development |
Volume | 25 |
Issue number | 14 |
DOIs | |
State | Published - Jul 15 2011 |
Keywords
- DHR3
- Drosophila
- E75
- Ecdysone
- Metabolism
- Metamorphosis
- Nitric oxide