TY - JOUR
T1 - NK3 receptor agonism reinstates temporal order memory in the hemiparkinsonian rat
AU - Chao, Owen Y.
AU - Wang, An Li
AU - Nikolaus, Susanne
AU - de Souza Silva, Maria A.
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/5/15
Y1 - 2015/5/15
N2 - Animals treated with unilateral 6-hydroxydopamine (6-ODHA) injections, an animal model of Parkinson's disease, exhibit deficits in memory for temporal order, but show intact novel object recognition. Since senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in the aged rat and to alleviate scopolamine-induced impairment, the present study aimed to assess possible promnestic effects of senktide in the hemiparkinsonian rat model. Animals received unilateral 6-ODHA microinjections into the medial forebrain bundle. Two weeks later, they were randomly assigned to treatment with vehicle, 0.2, or 0.4mg/kg senktide. Temporal order memory and place recognition tests were conducted, locomotor activity and turning behavior were assessed in the open field and anxiety-related behavior was measured in the light-dark box. Treatments were administered 30min prior to behavioral testing with an interval of seven days between tests. The animals treated with 0.2mg/kg senktide exhibited temporal order memory, unlike the vehicle-treated group. No significant treatment effects were found in the open field and light-dark box. Administration of 0.2mg/kg senktide may influence the prefrontal cortex and hippocampus, leading to compensations for deficits in memory for temporal order.
AB - Animals treated with unilateral 6-hydroxydopamine (6-ODHA) injections, an animal model of Parkinson's disease, exhibit deficits in memory for temporal order, but show intact novel object recognition. Since senktide, a potent neurokinin-3 receptor (NK3-R) agonist, has been shown to have promnestic effects in the aged rat and to alleviate scopolamine-induced impairment, the present study aimed to assess possible promnestic effects of senktide in the hemiparkinsonian rat model. Animals received unilateral 6-ODHA microinjections into the medial forebrain bundle. Two weeks later, they were randomly assigned to treatment with vehicle, 0.2, or 0.4mg/kg senktide. Temporal order memory and place recognition tests were conducted, locomotor activity and turning behavior were assessed in the open field and anxiety-related behavior was measured in the light-dark box. Treatments were administered 30min prior to behavioral testing with an interval of seven days between tests. The animals treated with 0.2mg/kg senktide exhibited temporal order memory, unlike the vehicle-treated group. No significant treatment effects were found in the open field and light-dark box. Administration of 0.2mg/kg senktide may influence the prefrontal cortex and hippocampus, leading to compensations for deficits in memory for temporal order.
KW - 6-OHDA
KW - NK receptor
KW - Parkinson's disease
KW - Senktide
KW - Temporal order memory
UR - http://www.scopus.com/inward/record.url?scp=84939881795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939881795&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2014.06.006
DO - 10.1016/j.bbr.2014.06.006
M3 - Article
C2 - 24928770
AN - SCOPUS:84939881795
SN - 0166-4328
VL - 285
SP - 208
EP - 212
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -