No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions

Thomas R. Hoye; Brian M. Eklov; Mikhail Voloshin

doi:10.1021/ol049145r

No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions

Thomas R. Hoye, Brian M. Eklov, Mikhail Voloshin

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

(Matrix Presented) The concentration of organolithium, organomagnesium halide, and lithium diisopropylamide solutions can be reliably determined using No-D NMR spectroscopy by integration against the added internal standard 1,5-cyclooctadiene (COD) (or cyclooctene). In addition, common impurities and degradation products can be assessed.

Original language	English (US)
Pages (from-to)	2567-2570
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	15
DOIs	https://doi.org/10.1021/ol049145r
State	Published - Jul 22 2004

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title = "No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions",

abstract = "(Matrix Presented) The concentration of organolithium, organomagnesium halide, and lithium diisopropylamide solutions can be reliably determined using No-D NMR spectroscopy by integration against the added internal standard 1,5-cyclooctadiene (COD) (or cyclooctene). In addition, common impurities and degradation products can be assessed.",

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AU - Hoye, Thomas R.

AU - Eklov, Brian M.

AU - Voloshin, Mikhail

PY - 2004/7/22

Y1 - 2004/7/22

N2 - (Matrix Presented) The concentration of organolithium, organomagnesium halide, and lithium diisopropylamide solutions can be reliably determined using No-D NMR spectroscopy by integration against the added internal standard 1,5-cyclooctadiene (COD) (or cyclooctene). In addition, common impurities and degradation products can be assessed.

AB - (Matrix Presented) The concentration of organolithium, organomagnesium halide, and lithium diisopropylamide solutions can be reliably determined using No-D NMR spectroscopy by integration against the added internal standard 1,5-cyclooctadiene (COD) (or cyclooctene). In addition, common impurities and degradation products can be assessed.

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No-D NMR spectroscopy as a convenient method for titering organolithium (RLi), RMgX, and LDA solutions

Abstract

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