Abstract
Smoking cigarettes increases the risk of developing chronic obstructive pulmonary disease (COPD), which is one of the leading causes of death. Cigarette smoke, in the form of secondhand smoke, can also adversely affect the respiratory health of children. Smoking cigarettes induces multiple interacting conditions that are likely to contribute to the development of COPD, including inflammation, perturbations in the balance between the activity of proteases and their inhibitors, and excessive exposure to oxidants. Interestingly, not all heavy smokers develop COPD. This suggests the susceptibility to COPD is determined by many characteristics, such as genetics and occupational exposures.
Original language | English (US) |
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Title of host publication | Comprehensive Toxicology, Third Edition |
Subtitle of host publication | Volume 1-15 |
Publisher | Elsevier |
Pages | V15-254-V15-262 |
Volume | 15 |
ISBN (Electronic) | 9780081006122 |
ISBN (Print) | 9780081006016 |
DOIs | |
State | Published - Jan 1 2018 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Ltd. All rights reserved.
Keywords
- Alpha-1-antitrypsin
- Asthma
- Children’s respiratory health
- Chronic obstructive pulmonary disease
- Cigarette smoke
- Emphysema
- Environmental tobacco smoke
- Gene–environment interactions
- Histone deacetylase
- Macrophages
- Matrix metalloprotease
- Neutrophils
- Noncancer respiratory disease
- Oxidative stress