TY - GEN
T1 - Noninvasive three-dimensional cardiac activation imaging of ventricular arrhythmias in the rabbit heart
AU - Han, Chengzong
AU - Pogwizd, Steven M.
AU - Killingsworth, Cheryl R.
AU - Yan, Jiajie
AU - He, Bin
PY - 2010
Y1 - 2010
N2 - In the present study, a physical-model based threedimensional (3-D) cardiac electrical imaging (3-DCEI) technique was evaluated with the aid of 3-D intra-cardiac mapping from 200 intramural sites during norepinephrine (NE) induced ventricular arrhythmias in the rabbit heart. Body surface potentials and intramural bipolar electrical recordings using plunge-needle electrodes were simultaneously measured in a closedchest condition in a healthy rabbit. The non-invasively imaged activation sequence correlated well with invasively easured counterparts, with an averaged correlation coefficient of 0.70, and a relative error of 0.30. The sites of initial activation were well localized to be within ∼5mm from the initiation sites determined from intra-cardiac mapping. The present experimental results suggest that the 3-DCEI approach can reconstruct 3-D ventricular global activation sequence and localize the origin of activation during focal ventricular arrhythmias.
AB - In the present study, a physical-model based threedimensional (3-D) cardiac electrical imaging (3-DCEI) technique was evaluated with the aid of 3-D intra-cardiac mapping from 200 intramural sites during norepinephrine (NE) induced ventricular arrhythmias in the rabbit heart. Body surface potentials and intramural bipolar electrical recordings using plunge-needle electrodes were simultaneously measured in a closedchest condition in a healthy rabbit. The non-invasively imaged activation sequence correlated well with invasively easured counterparts, with an averaged correlation coefficient of 0.70, and a relative error of 0.30. The sites of initial activation were well localized to be within ∼5mm from the initiation sites determined from intra-cardiac mapping. The present experimental results suggest that the 3-DCEI approach can reconstruct 3-D ventricular global activation sequence and localize the origin of activation during focal ventricular arrhythmias.
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M3 - Conference contribution
AN - SCOPUS:79953811159
SN - 9781424473182
T3 - Computing in Cardiology
SP - 125
EP - 127
BT - Computing in Cardiology 2010, CinC 2010
T2 - Computing in Cardiology 2010, CinC 2010
Y2 - 26 September 2010 through 29 September 2010
ER -