Abstract
Novelty detection is a primitive subcomponent of cognitive control that can be deficient in Parkinson's disease (PD) patients. Here, we studied the corticostriatal mechanisms underlying novelty-response deficits. In participants with PD, we recorded from cortical circuits with scalp-based electroencephalography (EEG) and from subcortical circuits using intraoperative neurophysiology during surgeries for implantation of deep brain stimulation (DBS) electrodes. We report three major results. First, novel auditory stimuli triggered midfrontal low-frequency rhythms; of these, 1-4 Hz "delta"rhythms were linked to novelty-Associated slowing, whereas 4-7 Hz "theta"rhythms were specifically attenuated in PD. Second, 32% of subthalamic nucleus (STN) neurons were response-modulated; nearly all (94%) of these were also modulated by novel stimuli. Third, response-modulated STN neurons were coherent with midfrontal 1-4 Hz activity. These findings link scalp-based measurements of neural activity with neuronal activity in the STN. Our results provide insight into midfrontal cognitive control mechanisms and how purported hyperdirect frontobasal ganglia circuits evaluate new information.
Original language | English (US) |
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Pages (from-to) | 469-485 |
Number of pages | 17 |
Journal | Cerebral Cortex |
Volume | 33 |
Issue number | 2 |
DOIs | |
State | Published - Jan 15 2023 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 Published by Oxford University Press.
Keywords
- cognitive control
- neuronal coherence
- neuronal spiking
- oddball task
- prefrontal cortex
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural