TY - JOUR
T1 - Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer
T2 - A Review of the Literature
AU - Karalexi, Maria A.
AU - Markozannes, Georgios
AU - Tagkas, Christos F.
AU - Katsimpris, Andreas
AU - Tseretopoulou, Xanthippi
AU - Tsilidis, Konstantinos K.
AU - Spector, Logan G.
AU - Schüz, Joachim
AU - Siahanidou, Tania
AU - Petridou, Eleni Th
AU - Ntzani, Evangelia E.
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - Few studies so far have examined the impact of nutritional status on the survival of children with cancer, with the majority of them focusing on hematological malignancies. We summarized published evidence reporting the association of nutritional status at diagnosis with overall survival (OS), event-free survival (EFS), relapse, and treatment-related toxicity (TRT) in children with cancer. Published studies on children with leukemia, lymphoma, and other solid tumors have shown that both under-nourished and over-nourished children at cancer diagnosis had worse OS and EFS. Particularly, the risk of death and relapse increased by 30–50% among children with leukemia with increased body mass index at diagnosis. Likewise, the risk of TRT was higher among malnourished children with osteosarcoma and Ewing sarcoma. Nutritional status seems to play a crucial role in clinical outcomes of children with cancer, thus providing a significant modifiable prognostic tool in childhood cancer management. Future studies with adequate power and longitudinal design are needed to further evaluate the association of nutritional status with childhood cancer outcomes using a more standardized definition to measure nutritional status in this population. The use of new technologies is expected to shed further light on this understudied area and give room to person-targeted intervention strategies.
AB - Few studies so far have examined the impact of nutritional status on the survival of children with cancer, with the majority of them focusing on hematological malignancies. We summarized published evidence reporting the association of nutritional status at diagnosis with overall survival (OS), event-free survival (EFS), relapse, and treatment-related toxicity (TRT) in children with cancer. Published studies on children with leukemia, lymphoma, and other solid tumors have shown that both under-nourished and over-nourished children at cancer diagnosis had worse OS and EFS. Particularly, the risk of death and relapse increased by 30–50% among children with leukemia with increased body mass index at diagnosis. Likewise, the risk of TRT was higher among malnourished children with osteosarcoma and Ewing sarcoma. Nutritional status seems to play a crucial role in clinical outcomes of children with cancer, thus providing a significant modifiable prognostic tool in childhood cancer management. Future studies with adequate power and longitudinal design are needed to further evaluate the association of nutritional status with childhood cancer outcomes using a more standardized definition to measure nutritional status in this population. The use of new technologies is expected to shed further light on this understudied area and give room to person-targeted intervention strategies.
KW - childhood cancer
KW - event-free survival
KW - nutritional status
KW - obesity
KW - overall survival
KW - relapse
KW - review
KW - treatment-related toxicity
KW - undernutrition
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U2 - 10.3390/diagnostics12102357
DO - 10.3390/diagnostics12102357
M3 - Review article
C2 - 36292046
AN - SCOPUS:85140798515
SN - 2075-4418
VL - 12
JO - Diagnostics
JF - Diagnostics
IS - 10
M1 - 2357
ER -