On the Alert for Cytokine Storm: Immunopathology in COVID-19

Lauren A. Henderson; Scott W. Canna; Grant S. Schulert; Stefano Volpi; Pui Y. Lee; Kate F. Kernan; Roberto Caricchio; Shawn Mahmud; Melissa M. Hazen; Olha Halyabar; Kacie J. Hoyt; Joseph Han; Alexei A. Grom; Marco Gattorno; Angelo Ravelli; Fabrizio De Benedetti; Edward M. Behrens; Randy Q. Cron; Peter A. Nigrovic

doi:10.1002/art.41285

On the Alert for Cytokine Storm: Immunopathology in COVID-19

Lauren A. Henderson, Scott W. Canna, Grant S. Schulert, Stefano Volpi, Pui Y. Lee, Kate F. Kernan, Roberto Caricchio, Shawn Mahmud, Melissa M. Hazen, Olha Halyabar, Kacie J. Hoyt, Joseph Han, Alexei A. Grom, Marco Gattorno, Angelo Ravelli, Fabrizio De Benedetti, Edward M. Behrens, Randy Q. Cron, Peter A. Nigrovic

Pediatrics - Rheumatology Division

Research output: Contribution to journal › Comment/debate › peer-review

494 Scopus citations

Abstract

Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19.

Original language	English (US)
Pages (from-to)	1059-1063
Number of pages	5
Journal	Arthritis and Rheumatology
Volume	72
Issue number	7
DOIs	https://doi.org/10.1002/art.41285
State	Published - Jul 1 2020

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© 2020, American College of Rheumatology

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Henderson, L. A., Canna, S. W., Schulert, G. S., Volpi, S., Lee, P. Y., Kernan, K. F., Caricchio, R., Mahmud, S., Hazen, M. M., Halyabar, O., Hoyt, K. J., Han, J., Grom, A. A., Gattorno, M., Ravelli, A., De Benedetti, F., Behrens, E. M., Cron, R. Q., & Nigrovic, P. A. (2020). On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis and Rheumatology, 72(7), 1059-1063. https://doi.org/10.1002/art.41285

Henderson, LA, Canna, SW, Schulert, GS, Volpi, S, Lee, PY, Kernan, KF, Caricchio, R, Mahmud, S, Hazen, MM, Halyabar, O, Hoyt, KJ, Han, J, Grom, AA, Gattorno, M, Ravelli, A, De Benedetti, F, Behrens, EM, Cron, RQ & Nigrovic, PA 2020, 'On the Alert for Cytokine Storm: Immunopathology in COVID-19', Arthritis and Rheumatology, vol. 72, no. 7, pp. 1059-1063. https://doi.org/10.1002/art.41285

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AU - Kernan, Kate F.

AU - Caricchio, Roberto

AU - Mahmud, Shawn

AU - Hazen, Melissa M.

AU - Halyabar, Olha

AU - Hoyt, Kacie J.

AU - Han, Joseph

AU - Grom, Alexei A.

AU - Gattorno, Marco

AU - Ravelli, Angelo

AU - De Benedetti, Fabrizio

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AU - Cron, Randy Q.

AU - Nigrovic, Peter A.

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On the Alert for Cytokine Storm: Immunopathology in COVID-19

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