Abstract
A variety of substituted acridones were synthesized via a one-pot, metal-free cascade reaction. In this event, the DBU-mediated addition between quinols and ortho-methoxycarbonylaryl isocyanates formed a bicyclic oxazolidinone, followed by a sequence of intramolecular condensation, tautomerization, and decarboxylation, which led to the formation of acridones. The acridones showed mild activity against the human cytomegalovirus.
Original language | English (US) |
---|---|
Pages (from-to) | 4515-4524 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 85 |
Issue number | 6 |
DOIs | |
State | Published - Mar 20 2020 |
Bibliographical note
Funding Information:We are grateful to Professors Richard Franck and Klaus Grohmann at Hunter College for helpful discussions. We also thank Drs. Barney Yoo, Matthew Devany, Michelle Neary, and Tony Hu for mass spectrometric, NMR spectroscopic, and X-ray crystallographic assistance, respectively. Financial support from the Bertha and Louis Weinstein Research Grant, NIH (SC2GM100783), NSF (CHE-1464543), and PSC–CUNY Research Award is gratefully acknowledged.
Publisher Copyright:
Copyright © 2020 American Chemical Society.