One-step facile synthesis of deuterium labeled aldehydes from tertiary amides using Cp2Zr(D)Cl

Jared T. Spletstoser; Jonathan M. White; Gunda I. Georg

doi:10.1016/j.tetlet.2004.02.030

One-step facile synthesis of deuterium labeled aldehydes from tertiary amides using Cp₂Zr(D)Cl

Jared T. Spletstoser, Jonathan M. White, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The synthesis of deuterium labeled aldehydes was accomplished in an expedient and facile manner through the reduction of amides using commercially available Cp₂Zr(D)Cl. The reactions proceeded rapidly (ca. 15min) and in high yields (70-99%).

Original language	English (US)
Pages (from-to)	2787-2789
Number of pages	3
Journal	Tetrahedron Letters
Volume	45
Issue number	13
DOIs	https://doi.org/10.1016/j.tetlet.2004.02.030
State	Published - Mar 22 2004

Keywords

Amide
CpZr(D)Cl
Deuterium labeled aldehyde
Reduction
Schwartz reagent
Zirconium

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10.1016/j.tetlet.2004.02.030

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title = "One-step facile synthesis of deuterium labeled aldehydes from tertiary amides using Cp2Zr(D)Cl",

abstract = "The synthesis of deuterium labeled aldehydes was accomplished in an expedient and facile manner through the reduction of amides using commercially available Cp2Zr(D)Cl. The reactions proceeded rapidly (ca. 15min) and in high yields (70-99%).",

keywords = "Amide, CpZr(D)Cl, Deuterium labeled aldehyde, Reduction, Schwartz reagent, Zirconium",

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T1 - One-step facile synthesis of deuterium labeled aldehydes from tertiary amides using Cp2Zr(D)Cl

AU - Spletstoser, Jared T.

AU - White, Jonathan M.

AU - Georg, Gunda I.

PY - 2004/3/22

Y1 - 2004/3/22

N2 - The synthesis of deuterium labeled aldehydes was accomplished in an expedient and facile manner through the reduction of amides using commercially available Cp2Zr(D)Cl. The reactions proceeded rapidly (ca. 15min) and in high yields (70-99%).

AB - The synthesis of deuterium labeled aldehydes was accomplished in an expedient and facile manner through the reduction of amides using commercially available Cp2Zr(D)Cl. The reactions proceeded rapidly (ca. 15min) and in high yields (70-99%).

KW - Amide

KW - CpZr(D)Cl

KW - Deuterium labeled aldehyde

KW - Reduction

KW - Schwartz reagent

KW - Zirconium

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