Optical Control of Microtubule Dynamics in Time and Space

Brian T. Castle; David J. Odde

doi:10.1016/j.cell.2015.06.064

Optical Control of Microtubule Dynamics in Time and Space

Brian T. Castle, David J. Odde

Biomedical Engineering

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.

Original language	English (US)
Article number	8312
Pages (from-to)	243-245
Number of pages	3
Journal	Cell
Volume	162
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2015.06.064
State	Published - Jul 18 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.cell.2015.06.064

OpenUrl availability

Full text

Cite this

@article{d20f7ffff1cb46f399e7f96f0784a5e6,

title = "Optical Control of Microtubule Dynamics in Time and Space",

abstract = "Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned {"}on{"} and {"}off{"} with low-intensity light to spatially and temporally control microtubule dynamics.",

author = "Castle, {Brian T.} and Odde, {David J.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = jul,

day = "18",

doi = "10.1016/j.cell.2015.06.064",

language = "English (US)",

volume = "162",

pages = "243--245",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Optical Control of Microtubule Dynamics in Time and Space

AU - Castle, Brian T.

AU - Odde, David J.

PY - 2015/7/18

Y1 - 2015/7/18

N2 - Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.

AB - Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.

UR - http://www.scopus.com/inward/record.url?scp=84937200933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937200933&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2015.06.064

DO - 10.1016/j.cell.2015.06.064

M3 - Short survey

C2 - 26186185

AN - SCOPUS:84937200933

SN - 0092-8674

VL - 162

SP - 243

EP - 245

JO - Cell

JF - Cell

IS - 2

M1 - 8312

ER -

Optical Control of Microtubule Dynamics in Time and Space

Abstract

Bibliographical note

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this