TY - JOUR
T1 - Otopathology in the United States
T2 - History, current situation, and future perspectives
AU - Da Costa Monsanto, Rafael
AU - Pauna, Henrique Furlan
AU - Paparella, Michael M.
AU - Cureoglu, Sebahattin
N1 - Publisher Copyright:
© 2018, Otology & Neurotology, Inc.
PY - 2018
Y1 - 2018
N2 - Human temporal bone studies have documented the pathophysiologic basis of many pathologic conditions and diseases affecting the ear, contributing to the development of specific clinical knowledge and pathology-oriented treatments. Researchers dedicated to the study of anatomy and histology of the temporal bone emanated from Europe to the United States during the first part of the 20th Century. The first otopathology laboratory was founded in the United States in 1924, at Johns Hopkins University; over time, the otopathology laboratories—considered by some authors as ‘‘gold mines’’ for studying ear diseases—became numerous and very prolific. However, today, only three of the temporal bone laboratories are still running and producing scientific knowledge to the Otology/Neurotology field: the ones at Harvard Medical School, University of Minnesota, and University of California. Molecular biologic assay techniques and new microscopy and computer equipment broadened the possibilities for temporal bone studies; however, the current funding for those laboratories are insufficient to cover the costs for processing and studying human temporal bones. The main objective of this study is to briefly describe the history, current situation, and future perspectives of the otopathology laboratories in the United States.
AB - Human temporal bone studies have documented the pathophysiologic basis of many pathologic conditions and diseases affecting the ear, contributing to the development of specific clinical knowledge and pathology-oriented treatments. Researchers dedicated to the study of anatomy and histology of the temporal bone emanated from Europe to the United States during the first part of the 20th Century. The first otopathology laboratory was founded in the United States in 1924, at Johns Hopkins University; over time, the otopathology laboratories—considered by some authors as ‘‘gold mines’’ for studying ear diseases—became numerous and very prolific. However, today, only three of the temporal bone laboratories are still running and producing scientific knowledge to the Otology/Neurotology field: the ones at Harvard Medical School, University of Minnesota, and University of California. Molecular biologic assay techniques and new microscopy and computer equipment broadened the possibilities for temporal bone studies; however, the current funding for those laboratories are insufficient to cover the costs for processing and studying human temporal bones. The main objective of this study is to briefly describe the history, current situation, and future perspectives of the otopathology laboratories in the United States.
KW - Genomics
KW - History
KW - Laboratories
KW - Otolaryngology
KW - Otopathology
KW - Pathology
KW - Proteomics
KW - Temporal bone
UR - http://www.scopus.com/inward/record.url?scp=85056506236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056506236&partnerID=8YFLogxK
U2 - 10.1097/MAO.0000000000001942
DO - 10.1097/MAO.0000000000001942
M3 - Article
C2 - 30106850
AN - SCOPUS:85056506236
SN - 1531-7129
VL - 39
SP - 1210
EP - 1214
JO - Otology and Neurotology
JF - Otology and Neurotology
IS - 9
ER -