TY - JOUR
T1 - Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection
AU - Kroon, Eugene
AU - Chottanapund, Suthat
AU - Buranapraditkun, Supranee
AU - Sacdalan, Carlo
AU - Colby, Donn J.
AU - Chomchey, Nitiya
AU - Prueksakaew, Peeriya
AU - Pinyakorn, Suteeraporn
AU - Trichavaroj, Rapee
AU - Vasan, Sandhya
AU - Manasnayakorn, Sopark
AU - Reilly, Cavan
AU - Helgeson, Erika
AU - Anderson, Jodi
AU - David, Caitlin
AU - Zulk, Jacob
AU - De Souza, Mark
AU - Tovanabutra, Sodsai
AU - Schuetz, Alexandra
AU - Robb, Merlin L.
AU - Douek, Daniel C.
AU - Phanuphak, Nittaya
AU - Haase, Ashley
AU - Ananworanich, Jintanat
AU - Schacker, Timothy W.
N1 - Publisher Copyright:
© 2022 The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2022/6/15
Y1 - 2022/6/15
N2 - Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.
AB - Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.
KW - HIV reservoir
KW - acute HIV infection
KW - antiretroviral therapy
KW - in situ hybridization
KW - lymphoid tissues
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U2 - 10.1093/infdis/jiac089
DO - 10.1093/infdis/jiac089
M3 - Article
C2 - 35275599
AN - SCOPUS:85132452194
SN - 0022-1899
VL - 225
SP - 2167
EP - 2175
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -
