Parcellation in left lateral parietal cortex is similar in adults and children

Kelly Anne Barnes; Steven M. Nelson; Alexander L. Cohen; Jonathan D. Power; Rebecca S. Coalson; Francis M. Miezin; Alecia C. Vogel; Joseph W. Dubis; Jessica A. Church; Steven E. Petersen; Bradley L. Schlaggar

doi:10.1093/cercor/bhr189

Parcellation in left lateral parietal cortex is similar in adults and children

Kelly Anne Barnes, Steven M. Nelson, Alexander L. Cohen, Jonathan D. Power, Rebecca S. Coalson, Francis M. Miezin, Alecia C. Vogel, Joseph W. Dubis, Jessica A. Church, Steven E. Petersen, Bradley L. Schlaggar

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31 Scopus citations

Abstract

A key question in developmental neuroscience involves understanding how and when the cerebral cortex is partitioned into distinct functional areas. The present study used functional connectivity MRI mapping and graph theory to identify putative cortical areas and generate a parcellation scheme of left lateral parietal cortex (LLPC) in 7 to 10-year-old children and adults. Results indicated that a majority of putative LLPC areas could be matched across groups (mean distance between matched areas across age: 3.15 mm). Furthermore, the boundaries of children's putative LLPC areas respected the boundaries generated from the adults' parcellation scheme for a majority of children's areas (13/15). Consistent with prior research, matched LLPC areas showed age-related differences in functional connectivity strength with other brain regions. These results suggest that LLPC cortical parcellation and functional connectivity mature along different developmental trajectories, with adult-like boundaries between LLPC areas established in school-age children prior to adult-like functional connectivity.

Original language	English (US)
Pages (from-to)	1148-1158
Number of pages	11
Journal	Cerebral Cortex
Volume	22
Issue number	5
DOIs	https://doi.org/10.1093/cercor/bhr189
State	Published - May 2012
Externally published	Yes

Bibliographical note

Funding Information:
National Institutes of Health (grants NS007205-28 to K.A.B., NS062489 to A.L.C., NS053425, HD057076, and MH091512 to B.L.S., and NS06114 and NS046424 to S.E.P.); Simons Foundation Autism Research Initiative.

Keywords

brain development
functional areas
functional connectivity
parietal lobe

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title = "Parcellation in left lateral parietal cortex is similar in adults and children",

abstract = "A key question in developmental neuroscience involves understanding how and when the cerebral cortex is partitioned into distinct functional areas. The present study used functional connectivity MRI mapping and graph theory to identify putative cortical areas and generate a parcellation scheme of left lateral parietal cortex (LLPC) in 7 to 10-year-old children and adults. Results indicated that a majority of putative LLPC areas could be matched across groups (mean distance between matched areas across age: 3.15 mm). Furthermore, the boundaries of children's putative LLPC areas respected the boundaries generated from the adults' parcellation scheme for a majority of children's areas (13/15). Consistent with prior research, matched LLPC areas showed age-related differences in functional connectivity strength with other brain regions. These results suggest that LLPC cortical parcellation and functional connectivity mature along different developmental trajectories, with adult-like boundaries between LLPC areas established in school-age children prior to adult-like functional connectivity.",

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AU - Cohen, Alexander L.

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AU - Miezin, Francis M.

AU - Vogel, Alecia C.

AU - Dubis, Joseph W.

AU - Church, Jessica A.

AU - Petersen, Steven E.

AU - Schlaggar, Bradley L.

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N2 - A key question in developmental neuroscience involves understanding how and when the cerebral cortex is partitioned into distinct functional areas. The present study used functional connectivity MRI mapping and graph theory to identify putative cortical areas and generate a parcellation scheme of left lateral parietal cortex (LLPC) in 7 to 10-year-old children and adults. Results indicated that a majority of putative LLPC areas could be matched across groups (mean distance between matched areas across age: 3.15 mm). Furthermore, the boundaries of children's putative LLPC areas respected the boundaries generated from the adults' parcellation scheme for a majority of children's areas (13/15). Consistent with prior research, matched LLPC areas showed age-related differences in functional connectivity strength with other brain regions. These results suggest that LLPC cortical parcellation and functional connectivity mature along different developmental trajectories, with adult-like boundaries between LLPC areas established in school-age children prior to adult-like functional connectivity.

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Parcellation in left lateral parietal cortex is similar in adults and children

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