Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Dae Hwan Suk; Dominik Rejman; Christine C. Dykstra; Radek Pohl; Krzysztof W. Pankiewicz; Steven E. Patterson

doi:10.1016/j.bmcl.2007.02.063

Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Dae Hwan Suk, Dominik Rejman, Christine C. Dykstra, Radek Pohl, Krzysztof W. Pankiewicz, Steven E. Patterson

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

Original language	English (US)
Pages (from-to)	2811-2816
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2007.02.063
State	Published - May 15 2007

Keywords

Cyst wall synthase
Encystation
Giardia
Nucleotide

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title = "Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent",

abstract = "Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.",

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T2 - Rational design and discovery of a potent nucleotide anti-Giardia agent

AU - Suk, Dae Hwan

AU - Rejman, Dominik

AU - Dykstra, Christine C.

AU - Pohl, Radek

AU - Pankiewicz, Krzysztof W.

AU - Patterson, Steven E.

PY - 2007/5/15

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KW - Giardia

KW - Nucleotide

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Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Abstract

Keywords

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