TY - JOUR
T1 - PKC-θ function at the immunological synapse
T2 - Prospects for therapeutic targeting
AU - Zanin-Zhorov, Alexandra
AU - Dustin, Michael L.
AU - Blazar, Bruce R.
N1 - Funding Information:
NIH grants PN2EY016586 (MLD), R01 HL56067, and P01 CA067493 (BRB) and Leukemia and Lymphoma Translational Research (grant R6029-07) (BRB)
PY - 2011/8
Y1 - 2011/8
N2 - Protein kinase C (PKC)-θ regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-θ in T cells is complex. PKC-θ plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-θ is required for the development of natural CD4 +Foxp3 + regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-θ in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-θ in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.
AB - Protein kinase C (PKC)-θ regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-θ in T cells is complex. PKC-θ plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-θ is required for the development of natural CD4 +Foxp3 + regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-θ in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-θ in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.
UR - http://www.scopus.com/inward/record.url?scp=79960894775&partnerID=8YFLogxK
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U2 - 10.1016/j.it.2011.04.007
DO - 10.1016/j.it.2011.04.007
M3 - Review article
C2 - 21733754
AN - SCOPUS:79960894775
SN - 1471-4906
VL - 32
SP - 358
EP - 363
JO - Trends in Immunology
JF - Trends in Immunology
IS - 8
ER -