Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells

Ekaterina Y. Lukianova-Hleb; Xiaoyang Ren; Joseph A. Zasadzinski; Xiangwei Wu; Dmitri O. Lapotko

doi:10.1002/adma.201103550

Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells

Ekaterina Y. Lukianova-Hleb, Xiaoyang Ren, Joseph A. Zasadzinski, Xiangwei Wu, Dmitri O. Lapotko

Chemical Engineering and Materials Science

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Plasmonic nanobubbles, new multifunctional cellular nano-agents, are selectively generated in target cancer cells with a short near-infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug-resistance of cancer cells.

Original language	English (US)
Pages (from-to)	3831-3837
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	28
DOIs	https://doi.org/10.1002/adma.201103550
State	Published - Jul 24 2012

Keywords

Doxil
cancer
drug resistance
gold nanoparticles
laser
plasmonic nanobubbles

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AU - Ren, Xiaoyang

AU - Zasadzinski, Joseph A.

AU - Wu, Xiangwei

AU - Lapotko, Dmitri O.

PY - 2012/7/24

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AB - Plasmonic nanobubbles, new multifunctional cellular nano-agents, are selectively generated in target cancer cells with a short near-infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug-resistance of cancer cells.

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KW - gold nanoparticles

KW - laser

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Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells

Abstract

Keywords

UN SDGs

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