TY - JOUR
T1 - Poly A:U‐Induced Secretion of T‐Lymphocyte Helper Factors
AU - BICK, P. H.
AU - JOHNSON, A. G.
PY - 1977/11
Y1 - 1977/11
N2 - In vitro exposure of mouse thymocytes to complexes of polyadenylic:polyuridylic acid (poly A:U) effected, within 6 h, the release of soluble factor(s) capable of nonspecifically enhancing IgM and IgG plaque‐forming cells (PFCs) in in vitro primary and secondary spleen cell responses to burro erythrocytes. Poly A:U stimulation was, most likely, polyclonal, since production of soluble factor(s) occurred in the absence of antigen and in serum‐free culture media. Poly A:U‐induced soluble factor(s) were not capable of substituting for T cells but were dependent on T cells for the expression of PFC enhancement. These data support the hypothesis that the mechanism of poly A:U's adjuvant action is polyclonal stimulation of T cells, causing early induction and release of nonspecific, soluble PFC‐enhancing factor(s).
AB - In vitro exposure of mouse thymocytes to complexes of polyadenylic:polyuridylic acid (poly A:U) effected, within 6 h, the release of soluble factor(s) capable of nonspecifically enhancing IgM and IgG plaque‐forming cells (PFCs) in in vitro primary and secondary spleen cell responses to burro erythrocytes. Poly A:U stimulation was, most likely, polyclonal, since production of soluble factor(s) occurred in the absence of antigen and in serum‐free culture media. Poly A:U‐induced soluble factor(s) were not capable of substituting for T cells but were dependent on T cells for the expression of PFC enhancement. These data support the hypothesis that the mechanism of poly A:U's adjuvant action is polyclonal stimulation of T cells, causing early induction and release of nonspecific, soluble PFC‐enhancing factor(s).
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U2 - 10.1111/j.1365-3083.1977.tb00352.x
DO - 10.1111/j.1365-3083.1977.tb00352.x
M3 - Article
C2 - 304244
AN - SCOPUS:0017720661
SN - 0300-9475
VL - 6
SP - 1133
EP - 1144
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
IS - 11
ER -