Potentiation of Warfarin Anticoagulation by Sulfisoxazole

Leo J. Sioris; Robert T. Weibert; Paul R. Pentel

doi:10.1001/archinte.1980.00330160106038

Potentiation of Warfarin Anticoagulation by Sulfisoxazole

Leo J. Sioris, Robert T. Weibert, Paul R. Pentel

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Abstract

The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.

Original language	English (US)
Pages (from-to)	546-547
Number of pages	2
Journal	Archives of Internal Medicine
Volume	140
Issue number	4
DOIs	https://doi.org/10.1001/archinte.1980.00330160106038
State	Published - Apr 1980

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Potentiation of Warfarin Anticoagulation by Sulfisoxazole

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