TY - JOUR
T1 - Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation
T2 - A Retrospective Study
AU - Abdelwahab, Nermine
AU - Ingraham, Nicholas E.
AU - Nguyen, Nguyen
AU - Siegel, Lianne
AU - Silverman, Greg
AU - Sahoo, Himanshu Shekhar
AU - Pakhomov, Serguei
AU - Morse, Leslie R.
AU - Billings, Joanne
AU - Usher, Michael G.
AU - Melnik, Tanya E.
AU - Tignanelli, Christopher J.
AU - Ikramuddin, Farha
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/10
Y1 - 2022/10
N2 - Objective: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC. Design: Retrospective study. Setting: Midwest hospital health system. Participants: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021. Intervention: Not applicable. Main Outcome Measures: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization. Results: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04). Conclusions: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.
AB - Objective: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC. Design: Retrospective study. Setting: Midwest hospital health system. Participants: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021. Intervention: Not applicable. Main Outcome Measures: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization. Results: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04). Conclusions: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.
KW - COVID-19
KW - Function
KW - Rehabilitation
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U2 - 10.1016/j.apmr.2022.04.009
DO - 10.1016/j.apmr.2022.04.009
M3 - Article
C2 - 35569640
AN - SCOPUS:85133857993
SN - 0003-9993
VL - 103
SP - 2001
EP - 2008
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 10
ER -
