Abstract
Congenital adrenal hyperplasia (C.A.H.) due to 21-hydroxylase deficiency is an HLA-linked recessive disorder. HLA-A and B antigens are expressed on amniotic cells. Prenatal diagnosis of C.A.H. by HLA typing of families and amniotic cells was attempted in two at-risk families. In one family HLA typing indicated that the fetus would have C.A.H., and this prediction was confirmed after birth. In the second family, HLA typing indicated that the fetus would be an unaffected, phenotypically normal carrier of the disease gene, and this prediction was also confirmed after birth.
Original language | English (US) |
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Pages (from-to) | 1107-1108 |
Number of pages | 2 |
Journal | The Lancet |
Volume | 313 |
Issue number | 8126 |
DOIs | |
State | Published - May 26 1979 |
Bibliographical note
Funding Information:This work was supported in part by grants from the U.S. Public Health Service CA 19267, CA 08748, CA 22507, RR47 and GM 191000, and NC1 and NIH contracts CB 84255-31 and AI 82557.