PREP-RELATED INTERACTIVE TOXICITY BELIEFS: ASSOCIATIONS WITH STIGMA, SUBSTANCE USE, AND PREP UPTAKE

Natalie M. Brousseau; Driver Redd; Kay Simon; Ryan J. Watson; Valerie A. Earnshaw; Cristian J. Chandler; Kalichman Seth; Lisa A. Eaton

doi:10.1521/AEAP.2023.35.2.114

PREP-RELATED INTERACTIVE TOXICITY BELIEFS: ASSOCIATIONS WITH STIGMA, SUBSTANCE USE, AND PREP UPTAKE

Natalie M. Brousseau, Driver Redd, Kay Simon, Ryan J. Watson, Valerie A. Earnshaw, Cristian J. Chandler, Kalichman Seth, Lisa A. Eaton

Family Social Science

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Despite documented efficacy in reducing HIV transmission, pre-exposure prophylaxis (PrEP) uptake among Black sexual minority men (BSMM) is limited. One understudied factor which may impede PrEP uptake is PrEPrelated interactive toxicity beliefs (i.e., believing it is hazardous to use alcohol/drugs while taking PrEP). Data from N = 169 HIV negative BSMM over 4 months showed high rates of agreement with at least one alcohol (78%) or drug (84%) interactive toxicity belief. Univariate analyses showed increased alcohol or drug interactive toxicity beliefs predicted lower PrEP uptake. Multivariable regression suggested those with PrEP-related alcohol or drug interactive toxicity beliefs were more likely to report high PrEP stigma, more negative PrEP beliefs (e.g., concern that taking PrEP disrupts life), and were more likely to use alcohol/drugs (respectively) prior to/during sex. Findings warrant intervention work targeting interactive toxicity beliefs with tailored messaging to mitigate PrEP stigma and correct concerns around substance use and PrEP.

Original language	English (US)
Pages (from-to)	114-125
Number of pages	12
Journal	AIDS Education and Prevention
Volume	35
Issue number	2
DOIs	https://doi.org/10.1521/AEAP.2023.35.2.114
State	Published - Apr 2023

Bibliographical note

Funding Information:
Natalie M. Brousseau, Ryan J. Watson, Seth Kalichman, and Lisa A. Eaton are affiliated with the Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, Connecticut. Redd Driver is affiliated with the HIV Center for Clinical and Behavioral Studies, Columbia University, New York, New York. Kay Simon is affiliated with the Department of Family Social Science, University of Minnesota, St. Paul, Minnesota. Valerie A. Earnshaw is affiliated with the Department of Human Development and Family Sciences, University of Delaware, Newark, Delaware. Cristian J. Chandler is affiliated with the Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee. This work was supported by the National Institutes of Health through the National Institute of Mental Health and the National Institute on Drug Abuse (R34MH115798 LAE; K01DA047918, RJW). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare that they have no conflicts of interest. They alone are responsible for the content and writing of the article. Address correspondence to Natalie M. Brousseau, InCHIP, 2006 Hillside Rd., Storrs, CT 06268. E-mail: nbrousseau@uconn.edu

Publisher Copyright:
© 2023 The Guilford Press.

Keywords

Black sexual minority men
PrEP stigma
PrEP uptake
alcohol use
interactive toxicity beliefs
substance use

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "PREP-RELATED INTERACTIVE TOXICITY BELIEFS: ASSOCIATIONS WITH STIGMA, SUBSTANCE USE, AND PREP UPTAKE",

abstract = "Despite documented efficacy in reducing HIV transmission, pre-exposure prophylaxis (PrEP) uptake among Black sexual minority men (BSMM) is limited. One understudied factor which may impede PrEP uptake is PrEPrelated interactive toxicity beliefs (i.e., believing it is hazardous to use alcohol/drugs while taking PrEP). Data from N = 169 HIV negative BSMM over 4 months showed high rates of agreement with at least one alcohol (78%) or drug (84%) interactive toxicity belief. Univariate analyses showed increased alcohol or drug interactive toxicity beliefs predicted lower PrEP uptake. Multivariable regression suggested those with PrEP-related alcohol or drug interactive toxicity beliefs were more likely to report high PrEP stigma, more negative PrEP beliefs (e.g., concern that taking PrEP disrupts life), and were more likely to use alcohol/drugs (respectively) prior to/during sex. Findings warrant intervention work targeting interactive toxicity beliefs with tailored messaging to mitigate PrEP stigma and correct concerns around substance use and PrEP.",

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note = "Funding Information: Natalie M. Brousseau, Ryan J. Watson, Seth Kalichman, and Lisa A. Eaton are affiliated with the Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, Connecticut. Redd Driver is affiliated with the HIV Center for Clinical and Behavioral Studies, Columbia University, New York, New York. Kay Simon is affiliated with the Department of Family Social Science, University of Minnesota, St. Paul, Minnesota. Valerie A. Earnshaw is affiliated with the Department of Human Development and Family Sciences, University of Delaware, Newark, Delaware. Cristian J. Chandler is affiliated with the Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee. This work was supported by the National Institutes of Health through the National Institute of Mental Health and the National Institute on Drug Abuse (R34MH115798 LAE; K01DA047918, RJW). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare that they have no conflicts of interest. They alone are responsible for the content and writing of the article. Address correspondence to Natalie M. Brousseau, InCHIP, 2006 Hillside Rd., Storrs, CT 06268. E-mail: nbrousseau@uconn.edu Publisher Copyright: {\textcopyright} 2023 The Guilford Press.",

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N2 - Despite documented efficacy in reducing HIV transmission, pre-exposure prophylaxis (PrEP) uptake among Black sexual minority men (BSMM) is limited. One understudied factor which may impede PrEP uptake is PrEPrelated interactive toxicity beliefs (i.e., believing it is hazardous to use alcohol/drugs while taking PrEP). Data from N = 169 HIV negative BSMM over 4 months showed high rates of agreement with at least one alcohol (78%) or drug (84%) interactive toxicity belief. Univariate analyses showed increased alcohol or drug interactive toxicity beliefs predicted lower PrEP uptake. Multivariable regression suggested those with PrEP-related alcohol or drug interactive toxicity beliefs were more likely to report high PrEP stigma, more negative PrEP beliefs (e.g., concern that taking PrEP disrupts life), and were more likely to use alcohol/drugs (respectively) prior to/during sex. Findings warrant intervention work targeting interactive toxicity beliefs with tailored messaging to mitigate PrEP stigma and correct concerns around substance use and PrEP.

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PREP-RELATED INTERACTIVE TOXICITY BELIEFS: ASSOCIATIONS WITH STIGMA, SUBSTANCE USE, AND PREP UPTAKE

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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