Production and dosimetry of [14O]water for PET activation studies

Munawwar Sajjad; Mehran R. Zaini; Jeih San Liow; David A. Rottenberg; Stephen C. Strother

doi:10.1016/S0969-8043(02)00175-6

Production and dosimetry of [¹⁴O]water for PET activation studies

Munawwar Sajjad, Mehran R. Zaini, Jeih San Liow, David A. Rottenberg, Stephen C. Strother

University of Minnesota Twin Cities

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

[¹⁴O]water was produced by the ¹⁴N(p,n)¹⁴O reaction in quantities greater than 80mCi (EOB). The carbon-11 impurity in the final product was approximately 0.003±0.002% of ¹⁴O activity at EOB. A factor of 0.5±0.02 was obtained to correct the dose calibrator for the additional 2.313MeV γ-ray. The effective dose equivalent was calculated for ¹⁴O and ¹⁵O using MIRDOSE, and the ¹⁴O dose was found to be ≈70% of that for ¹⁵O. For scanner performance based on noise equivalent count measurements, the peak activity concentration for ¹⁴O was 30% lower than that for ¹⁵O. At their peak activity concentrations the noise equivalent count rate for ¹⁴O was found to be about 13% less than that for ¹⁵O.

Original language	English (US)
Pages (from-to)	607-615
Number of pages	9
Journal	Applied Radiation and Isotopes
Volume	57
Issue number	5
DOIs	https://doi.org/10.1016/S0969-8043(02)00175-6
State	Published - Nov 1 2002

Bibliographical note

Funding Information:
This work was partly supported by the National Institutes of Health grants MH57180 and NS33721.

Keywords

O
PET

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title = "Production and dosimetry of [14O]water for PET activation studies",

abstract = "[14O]water was produced by the 14N(p,n)14O reaction in quantities greater than 80mCi (EOB). The carbon-11 impurity in the final product was approximately 0.003±0.002% of 14O activity at EOB. A factor of 0.5±0.02 was obtained to correct the dose calibrator for the additional 2.313MeV γ-ray. The effective dose equivalent was calculated for 14O and 15O using MIRDOSE, and the 14O dose was found to be ≈70% of that for 15O. For scanner performance based on noise equivalent count measurements, the peak activity concentration for 14O was 30% lower than that for 15O. At their peak activity concentrations the noise equivalent count rate for 14O was found to be about 13% less than that for 15O.",

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AU - Zaini, Mehran R.

AU - Liow, Jeih San

AU - Rottenberg, David A.

AU - Strother, Stephen C.

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AB - [14O]water was produced by the 14N(p,n)14O reaction in quantities greater than 80mCi (EOB). The carbon-11 impurity in the final product was approximately 0.003±0.002% of 14O activity at EOB. A factor of 0.5±0.02 was obtained to correct the dose calibrator for the additional 2.313MeV γ-ray. The effective dose equivalent was calculated for 14O and 15O using MIRDOSE, and the 14O dose was found to be ≈70% of that for 15O. For scanner performance based on noise equivalent count measurements, the peak activity concentration for 14O was 30% lower than that for 15O. At their peak activity concentrations the noise equivalent count rate for 14O was found to be about 13% less than that for 15O.

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