Prostaglandins as reducing agents: A model of adenylate cyclase activation?

D. A. Peterson; B. Kelly; N. Mehta; J. M. Gerrard

doi:10.1016/0090-6980(88)90012-3

Prostaglandins as reducing agents: A model of adenylate cyclase activation?

D. A. Peterson, B. Kelly, N. Mehta, J. M. Gerrard

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Abstract

It has been suggested that adenylate cyclase activation involves reduction of a disulfide linkage. Prostaglandin E₁ (PGE₁), prostaglandin E₂ (PGE₂), prostaglandin I₂ (PGI₂) and prostaglandin F₂α (PGF_2α) were tested for their ability to act as reducing agents with either cytochrome c, or the disulfide 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB), the latter with a catalytic amount of ferric chloride. PGE₁, PGE₂, and PGI₂ significantly reduced cytochrome c while PGF_2α did not. PGE₁, PGE₂ and PGI₂ reduced DTNB while PGF_2α did not. The results are consistent with the postulate that prostaglandins which are effective in activating adenylate cyclase can act as reducing agents and might be involved in reductive activation of adenylate cyclase.

Original language	English (US)
Pages (from-to)	667-671
Number of pages	5
Journal	Prostaglandins
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/0090-6980(88)90012-3
State	Published - Nov 1988
Externally published	Yes

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title = "Prostaglandins as reducing agents: A model of adenylate cyclase activation?",

abstract = "It has been suggested that adenylate cyclase activation involves reduction of a disulfide linkage. Prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), prostaglandin I2 (PGI2) and prostaglandin F2α (PGF2α) were tested for their ability to act as reducing agents with either cytochrome c, or the disulfide 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB), the latter with a catalytic amount of ferric chloride. PGE1, PGE2, and PGI2 significantly reduced cytochrome c while PGF2α did not. PGE1, PGE2 and PGI2 reduced DTNB while PGF2α did not. The results are consistent with the postulate that prostaglandins which are effective in activating adenylate cyclase can act as reducing agents and might be involved in reductive activation of adenylate cyclase.",

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T1 - Prostaglandins as reducing agents

T2 - A model of adenylate cyclase activation?

AU - Peterson, D. A.

AU - Kelly, B.

AU - Mehta, N.

AU - Gerrard, J. M.

PY - 1988/11

Y1 - 1988/11

N2 - It has been suggested that adenylate cyclase activation involves reduction of a disulfide linkage. Prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), prostaglandin I2 (PGI2) and prostaglandin F2α (PGF2α) were tested for their ability to act as reducing agents with either cytochrome c, or the disulfide 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB), the latter with a catalytic amount of ferric chloride. PGE1, PGE2, and PGI2 significantly reduced cytochrome c while PGF2α did not. PGE1, PGE2 and PGI2 reduced DTNB while PGF2α did not. The results are consistent with the postulate that prostaglandins which are effective in activating adenylate cyclase can act as reducing agents and might be involved in reductive activation of adenylate cyclase.

AB - It has been suggested that adenylate cyclase activation involves reduction of a disulfide linkage. Prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), prostaglandin I2 (PGI2) and prostaglandin F2α (PGF2α) were tested for their ability to act as reducing agents with either cytochrome c, or the disulfide 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB), the latter with a catalytic amount of ferric chloride. PGE1, PGE2, and PGI2 significantly reduced cytochrome c while PGF2α did not. PGE1, PGE2 and PGI2 reduced DTNB while PGF2α did not. The results are consistent with the postulate that prostaglandins which are effective in activating adenylate cyclase can act as reducing agents and might be involved in reductive activation of adenylate cyclase.

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Prostaglandins as reducing agents: A model of adenylate cyclase activation?

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